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Updated: Jan 18, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
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增加I类MHC表达的因素可能会导致免疫检查点抑制剂诱导糖尿病的发展

Lilach Aizenbud1, Noam Savion Gaiger1,2, Ana Luisa Perdigoto3,4

  • 1Medical Oncology, Yale University, New Haven, Connecticut, USA.

Journal for immunotherapy of cancer
|September 11, 2025
PubMed
概括

一种特定的基因变异,NLRC5Pro191Leu,在患有免疫检查点抑制剂的免疫相关糖尿病患者中更为常见. 这一发现表明这种严重副作用的潜在机制.

关键词:
糖尿病 糖尿病 糖尿病免疫检查点抑制剂 免疫检查点抑制剂免疫相关不良事件 - irAEAE主要组织相容性复杂 - - MHC.

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