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"点尿CA19-9可以成为儿童下尿路功能障碍的潜在生物标志物吗?"

Turker Altuntas¹, Mehmet Umut Kutukoglu², Onur Can Ozkan³

¹Department of Urology, School of Medicine, Marmara University, Istanbul, Turkey.

Journal of pediatric urology

|September 11, 2025

概括

尿液CA 19-9显示为诊断儿童下尿路功能障碍 (LUTD) 的生物标志物具有前途. 虽然有效地将LUTD与对照区分开来,但其与上泌尿道损伤和尿动力学参数的相关性需要进一步调查.

科学领域:

儿科泌尿外科儿科泌尿外科
生物标志物发现发现
尿动力学尿动力学尿动力学

背景情况:

儿童下尿路功能障碍 (LUTD) 存在诊断方面的挑战.
识别可靠的生物标志物对于准确的诊断和管理至关重要.
目前的诊断方法可能具有侵入性或缺乏特异性.

研究的目的:

评估尿液CA 19-9作为LUTD儿童潜在的诊断生物标志物.
评估尿液CA 19-9水平与潜在病理,包括上尿路损伤之间的相关性.
为了研究尿液CA 19-9和尿动力学参数之间的关系.

主要方法:

一项涉及200名儿童 (5-16岁) 的前性研究,分为神经性LUTD,非神经性LUTD和对照组.
用ELISA测量了尿中的CA 19-9水平.
组间进行了对比,并分析了与尿动力学参数和非侵入性措施的相关性. 在ROC分析中确定了值.

主要成果:

与对照组 (49.87 U/ml) 相比,神经性 (77.34 U/ml) 和非神经性 (58.63 U/ml) LUTD组的尿液CA 19-9水平显著更高 (p < 0.001).
在尿路CA 19-9和UUT损伤,detrusor泄漏点压力或合规性之间没有发现显著的相关性.
只有在尿路CA 19-9和空虚后残留物 (PVR) 之间观察到显著的相关性.

结论:

尿液CA 19-9是诊断儿科神经性和非神经性LUTD的潜在生物标志物.
它的诊断实用性在区分LUTD患者与健康对照患者方面得到了证明.
需要对更大的队列进行进一步的研究,以确定与UUT损伤和尿动力学参数的相关性.

关键词:

生物标志物生物标志物下泌尿道的症状下泌尿道的症状斑点性尿斑点性尿尿道CA 19-9 尿道

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