大动脉狭窄和外围动脉疾病:通过导管大动脉置换术后对死亡率的影响
Martin Faure1, Louis Le Bivic2, Marouane Boukhris2
1Department of Clinical and Research Data Center, Limoges University Hospital, 87000 Limoges, France; Inserm U1094, IRD UMR270, EpiMaCT - Epidemiology of chronic diseases in tropical zone, OmegaHealth, University of Limoges, Limoges University Hospital, 87025 Limoges, France.
Archives of cardiovascular diseases
|September 11, 2025
概括
周围动脉疾病 (PAD) 在大动脉狭窄 (AS) 患者中很常见,并独立增加死亡风险. 这种增加的风险甚至在没有冠状动脉疾病的情况下仍然存在,并且其存在不会改变.
科学领域:
- 心脏病学 心脏病学
- 血管医学 血管医学
- 老年医学 老年医学
背景情况:
- 周围动脉疾病 (PAD) 和性大动脉狭窄 (AS) 具有共同的风险因素和病理生理学.
- 在AS患者中PAD的患病率和预后影响需要进一步研究.
研究的目的:
- 确定在经过过导管大动脉置换 (TAVR) 的严重AS患者中PAD患病率.
- 评估PAD对TAVR后长期死亡率的影响.
主要方法:
- 对904名接受TAVR (2014-2023) 的患者进行了回顾性队列研究.
- 通过临床诊断,CT血管造影或先前的再血管化来定义PAD.
- 使用生存分析评估的长期死亡率.
主要成果:
- 23.5%的患者患有PAD.
- PAD与明显更高的死亡率相关 (aHR为1.31,P=0.029).
- 在冠状动脉疾病 (CAD) 独立的情况下,PAD增加了死亡风险.
结论:
- PAD是严重性AS死亡率增加的独立预测因子.
- 在AS中PAD的预后影响不受CAD的改变.
- 患有AS和PAD的患者应被确定为死亡风险高的患者.
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