POMCTRPM2BAT

Ju Hwan Yang1, Arbi Bahtiar Boedi Iman Halanobis1,2, Eun-Hye Byeon1

  • 1Department of Physiology, Institute of Medical Sciences, Gyeongsang National University College of Medicine, Jinju, Republic of Korea.

PubMed
概括

研究人员发现,POMC神经元中的暂时受体潜在拉斯2 (TRPM2) 调节棕色脂肪组织 (BAT) 热生成. 激活这些POMCTRPM2神经元促进能量消耗和体温,为代谢障碍治疗提供了洞察力.

相关概念视频

Thermoregulation01:26

Thermoregulation

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
2.3K
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
33.7K
Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.3K