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Updated: Jun 6, 2026

Genome-wide Mapping of Protein-DNA Interactions with ChEC-seq in Saccharomyces cerevisiae
10:43

Genome-wide Mapping of Protein-DNA Interactions with ChEC-seq in Saccharomyces cerevisiae

Published on: June 3, 2017

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将CRISPR扫描与使用双链DNA脱氨酶的向色素可访问性概况相结合.

Heejin Roh1,2, Simon P Shen1,2, Yan Hu2,3

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

Nature methods
|September 11, 2025
PubMed
概括

我们开发了针对性去氨酶可访问的染色质测序 (TDAC-seq),以分析单个DNA分子中的染色质可访问性. 这种基因组编辑方法将基因变化与单核酸分辨率的染色质可访问性联系起来.

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