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体重变化对大学生血压的长度影响
Nobuko Yamada-Goto1,2, Nahomi Sei3, Ayano Murai-Takeda3,4
1Keio University Health Center, Kanagawa, Japan. nyamadagoto@keio.jp.
概括
成年早期的体重变化显著影响血压 (BP). 体重增加会增加血压,而体重减轻会降低血压,显著的性别特异性差异和对缩血压的更强烈影响,特别是在男性中.
科学领域:
- 心血管健康 心血管健康
- 公共卫生 公共卫生
- 人体生理学 人体生理学
背景情况:
- 与肥胖相关的高血压在日本越来越令人担忧.
- 关于早期成年期体重波动对血压 (BP) 的长期影响的数据有限.
研究的目的:
- 在日本大学生中调查体重变化与血压 (BP) 之间的纵向关系.
- 分析体重变化的性别特异性模式和剂量依赖性关联,以及心和腹血压.
主要方法:
- 在三年内 (2013-2016年和随访期间) 对20929名大学生健康检查数据的纵向分析.
- 将学生分为七个重量变化组 (百分比变化).
- 性别分层分析和受限立方线 (RCS) 模型,以评估体重变化和血压变化 (ΔSBP/ΔDBP) 之间的关联.
主要成果:
- 体重增加与血压升高相关 (静缩和静缩),而体重减轻与血压降低相关.
- 观察到显著的关联:体重增加>3%的男性增加BP;体重增加>5%的女性增加SBP.
- 减肥>3%降低了男性的SBP;>10%的减肥降低了男性的DBP和女性的SBP. RCS模型显示非线性,剂量依赖性和性别特异性模式.
结论:
- 在三年内,即使是适度的体重变化也会对年轻成年人血压产生重大影响.
- 缩血压对体重变化的反应比腹缩血压更快,在男性中观察到更强烈的影响.
- 防止年轻成人体重增加可能为心血管健康带来重大公共卫生益处.
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