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用激光折射手术技术预防性交叉链接与仅用激光折射手术技术治疗近视的角膜稳定性比较:一个元分析

Shuang-An Yang^1,2, Shiow-Wen Liou³, Chun-Chen Chen^4,5

¹Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

|September 11, 2025

概括

与激光折射手术相结合的角膜交叉连接 (CXL) 与单独的激光手术相比,在近视患者中提高角膜稳定性. 这种组合特别有利于近视较高的人或接受LASIK的人,在手术后的第一年内改善视觉结果.

科学领域:

眼科医生眼科眼科
角膜外科手术角膜外科手术
折射手术是一种折射手术.

背景情况:

使用激光折射手术纠正近视是常见的.
手术后保持角膜稳定性对于长期的视觉结果至关重要.
角膜交叉连接 (CXL) 是一种加强角膜的程序.

研究的目的:

为了评估与激光折射手术相结合的角膜交叉链接 (CXL) 是否提供比单独的激光手术更好的角膜稳定性.
评估预防性CXL对近视患者视觉结果和角膜稳定性的影响.

主要方法:

在2023年8月之前,对五个电子数据库进行系统搜索.
包括比较预防性CXL与激光折射手术与仅在近视眼中进行激光手术的研究.
使用随机效应模型对12项研究 (1252只眼睛) 的元分析,分析了角质测量,折射,视力敏度和角膜厚度.

主要成果:

与激光手术一起的预防性CXL显示,与单独的激光手术相比,在手术后12个月内,未纠正和纠正距离视力敏度的下降明显较小.
患有较高近视 (球体等值 ≤ -5.0 D) 或接受LASIK的患者在预防性CXL时经历了更大的视觉稳定性.
两组之间没有发现有效性或可预测性的显著差异.

结论:

预防性CXL与激光折射手术相结合,与单独的激光手术相比,在近视患者中,在一年内改善角膜稳定性和视觉结果.
预防性CXL的好处在较高近视或接受LASIK的患者中更为明显.
这种组合方法提供了可比的疗效和可预测性,同时增强了长期的角膜稳定性.

关键词:

角膜交叉连接 (CXL) 是一个焦质折射晶片提取 (KLEx) 是一种激光辅助的 in situ 角质化 (LASIK) 技术近视; 视力敏 (VA)光折射性角膜切除术 (PRK) 是一种光折射性切除术.小切口镜片提取 (SMILE) 的方法

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