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全球血清中性和多性基物质暴露及其与脂质的相关性:系统性审查和元分析

Chao Ji¹, Marian Pavuk¹, Patricia Ruiz¹

¹Agency for Toxic Substances and Disease Registry (ATSDR), Centers for Disease Control and Prevention (CDC), 4770 Buford Hwy NE, MS S106-5, Atlanta, Georgia 30341, United States.

Environmental science & technology

|September 12, 2025

概括

和多基物质 (PFAS) 暴露与成人高胆固醇水平有关. 这一系统性审查发现,PFOA和PFOS等遗留PFAS与增加的总和LDL胆固醇之间存在一致的关联.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
流行病学流行病学

背景情况:

和多基基物质 (PFAS) 是广泛使用的合成化学品,对环境和健康的担忧越来越大.
以前的研究表明,PFAS暴露与血清脂质变化之间存在关联,但研究结果不一致.
遗留的PFAS,包括 perfluorooctanoic acid (PFOA) 和 perfluorooctanesulfonic acid (PFOS),经常被检测到.

研究的目的:

对PFAS暴露和血清脂质概况的流行病学研究进行系统审查和元分析.
澄清特定遗留PFAS与成年人,儿童和孕妇的脂质水平之间的关联.
确定研究缺口,特别是关于PFAS替代品和混合物.

主要方法:

在2023年12月之前发表的74项流行病学研究进行了系统审查和元分析.
包括检查不同人群 (成人,儿童,孕妇) 和环境中的PFAS暴露的研究.
利用元分析和标志测试来评估PFAS和血清脂质之间的关联.

主要成果:

在成年人中发现了PFOA和PFOS暴露与增加的总胆固醇和低密度脂蛋白 (LDL) 胆固醇之间的积极关联.
在成年人中,没有明显的证据表明高密度脂蛋白 (HDL) 胆固醇或总甘油三和高密度脂蛋白 (HDL) 胆固醇之间存在关联.
对孕妇的研究没有显示PFAS暴露和脂质配置文件之间的显著关联.

结论:

遗留的PFAS,特别是PFOA和PFOS,与不良的脂质变化有关,特别是成年人总和LDL胆固醇的升高.
目前的证据并没有强烈地将PFAS暴露与孕妇显著的脂质变化联系起来.
未来的研究应该涉及PFAS替代品和复杂混合物暴露,以提供全面的理解.

关键词:

地理变化地理变化高暴露与一般暴露.这是一个元分析.通过和多醇基物质 (PFAS)血清脂质血清脂质血清脂质

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