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循环设计的溶剂选择 - 弥合过程需求和可持续性目标
Michael U Luescher1, Alessia Valotta2, Julien Haber1
1Chemical & Analytical Development, Novartis Pharma AG, CH-4056 Basel, Switzerland.. michael-1.luescher@novartis.com.
Chimia
|September 12, 2025
概括
制药行业可以通过采用循环经济原则来提高可持续性,专注于高效的溶剂选择,以最大限度地减少制药活性成分 (API) 制造中的浪费和资源消耗.
科学领域:
- 制药制造业 制药制造业 制药制造业
- 环境科学 环境科学
- 绿色化学 绿色化学
背景情况:
- 制药行业面临着环境挑战,包括大量的废物产生和原材料提取和活性药物成分 (API) 制造造成的资源枯竭.
- 线性经济模式有助于这些环境问题,需要转向可持续实践.
- 溶剂使用是制药过程中输入量和废物的主要组成部分,这突出显示它是改进的关键领域.
研究的目的:
- 检查循环经济原则在制药工艺设计中的溶剂选择中的应用.
- 强调溶剂选择的重要性,作为实现可持续制药发展的关键因素.
- 探索如何将资源效率和废物最小化融入制药业务.
主要方法:
- 审查与化学过程设计相关的循环经济原则.
- 在制药生产中使用溶剂的分析.
- 循环溶剂选择策略的案例研究或理论检查.
主要成果:
- 循环经济原则为提高制药业务的可持续性提供了一个可行的框架.
- 以循环经济原则为指导的战略溶剂选择可以显著减少废物和资源消耗.
- 将循环性纳入溶剂选择中对于可持续的制药发展至关重要.
结论:
- 采用循环经济原则,特别是在溶剂选择方面,对于更可持续的制药行业至关重要.
- 这种方法既有利于环境健康,也有利于社区福祉.
- 可持续的溶剂策略是制药工艺设计未来的核心.
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