在重度抑郁和健康志愿者中,在重复的负面思维过程中增加了岛屿功能连接性
Landon S Edwards1, Saampras Ganesan2,3, Jolene Tay1
1Laureate Institute for Brain Research, Tulsa, OK, USA.
Psychological medicine
|September 12, 2025
概括
大型抑郁症 (MDD) 涉及重复的负面思维 (RNT). 脑部扫描显示RNT期间MDD患者的岛屿功能连接 (FC) 发生变化,突出了情绪处理中的神经差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 重复的负面思维 (RNT) 是主要抑郁障碍 (MDD) 的标志.
- 以前的研究将岛屿功能连接 (FC) 与MDD中的RNT强度联系起来.
- 这项研究研究了MDD和健康对照 (HC) 中静止状态的岛屿FC差异与RNT诱导.
研究的目的:
- 在患有重度抑郁症 (MDD) 的人和健康对照者 (HC) 中,比较休息状态和重复负面思维 (RNT) 诱导之间的岛屿功能连接 (FC) 模式.
- 通过检查不同认知状态下岛屿子区域连接如何变化来探索MDD中RNT的神经基础.
主要方法:
- 功能性磁共振成像 (fMRI) 扫描在休息状态和RNT诱导期间对41名MDD患者和28名HC参与者进行了扫描.
- 进行了种子对整个大脑分析,使用岛屿子区域作为种子来检查功能连接模式.
主要成果:
- 与HC相比,MDD参与者在岛屿区域和小脑之间表现出更大的FC.
- 在RNT诱导过程中,MDD和HC组都在前/中岛和前额/双额区域之间增加了FC.
- 探索性分析揭示了特征/状态RNT严重程度和MDD中连接到默认模式网络 (DMN) 和突出网络 (SN) 的岛屿区域中增加的FC之间的相关性.
结论:
- 在活跃的反过程中增加的岛屿超连接性,特别是涉及DMN和SN,支持了抑郁症中自我集中和负面情绪处理增加的理论.
- 这些发现阐明了MDD中主动引起的RNT的神经支.
- 这项研究强调了岛屿电路在主要抑郁症中RNT病理生理学的作用.
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