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在健康成年人中通过摄入富含莱科的番茄汁改善血管内皮功能:随机,安慰剂控制,双盲,并行组比较研究
Kazutaka Yoshida1, Yuichiro Nakazawa1, Shingo Takahashi1
1Diet & Well-being Research Institute, Kagome Co., Ltd, 329-2762, 17 Nishitomiyama, Nasushiobara, Tochigi, Japan. Kazutaka_Yoshida@kagome.co.jp.
Food & function
|September 12, 2025
概括
从番茄汁中摄入的素显著改善了血管内皮功能,通过流媒体扩张 (FMD) 测量,在健康的成年人中超过12周. 这表明了烯.
科学领域:
- 心血管健康 心血管健康
- 营养科学 营养科学
- 人体生理学 人体生理学
背景情况:
- 血管内皮功能对于预防动脉硬化至关重要.
- 流介导扩张 (FMD) 是内皮健康的关键指标.
- 在服用4周后,烯对口炎的影响需要进一步调查.
研究的目的:
- 为了评估富含利科的番茄汁对血管内皮功能的影响.
- 为了评估口病,血清白甘,氧化应激和氧化水平的变化.
- 为了确定在内皮功能上适用的利科干预的最佳持续时间.
主要方法:
- 一个为期12周的随机,安慰剂控制,双盲试验,涉及75名患有边缘性口炎的健康成年人.
- 参与者服用了安慰剂果汁 (0.7毫克红),西红汁 (TJ,15.0毫克) 或高红汁 (HLTJ,26.7毫克).
- 测量包括口病,血清甘,氧化应激标志物和4周间隔的氧化度.
主要成果:
- 与安慰剂 (5.4 ± 0.6%) 相比,在TJ (6.1 ± 0.5%) 和HLTJ (7.0 ± 0.7%) 组中,在12周内口病的显著改善.
- 与安慰剂相比,HLTJ组在第4周和第8周表现出明显更高的口炎.
- 在TJ和HLTJ群体中,血清甘水平显著增加;没有观察到氧化应激或氧化水平的显著变化.
结论:
- 摄入利科,特别是来自番茄汁,在健康的成年人中有效地改善了血管内皮功能.
- 对口热的好处早在4周就被观察到,持续到12周.
- 虽然烯增强了口病,但独立于氧化应激和氧化的潜在机制需要进一步阐明.
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