在青春期棕鱼 (Salmo trutta) 中,父母对甲基化的影响比温度更强烈
Shenglin Liu1, Bror Jonsson2, Larry Greenberg3
1Department of Biology Aarhus University Aarhus C Denmark.
Ecology and evolution
|September 12, 2025
概括
父母的生命史,而不是早期的温度,显著影响棕鱼后代的DNA甲基化. 这表明跨代表观遗传效应对人口适应的环境条件比早期的生活条件更有影响力.
科学领域:
- 表观遗传学和环境变化
- 水生生态学 水生生态学
- 跨代人的遗产.
背景情况:
- 像DNA甲基化这样的表观遗传修饰是表型可塑性和对环境变化的跨代反应的关键.
- 了解早期生活环境条件如何影响表观遗传模式对于预测人口适应至关重要.
研究的目的:
- 为了研究温度诱导的DNA甲基化变化的持久性,在青棕鱼中.
- 评估父母生活史在塑造后代甲基化模式中的作用.
主要方法:
- 在第一次养之前,不同家长类型的棕鱼蛋暴露在环境或升高的温度 (+3°C) 中.
- 幼在常规条件下养,在受精后10.5个月进行全基因组二硫酸盐测序.
主要成果:
- 发现了持续的温度诱导的DNA甲基化变化的微弱证据,父母类型之间几乎没有重叠.
- 父母的生命史,特别是母亲的起源,显著影响了后代的甲基化模式.
- 母性衍生的甲基化差异在与新陈代谢和神经系统功能相关的基因中得到丰富.
结论:
- 生命早期的热条件对棕鱼的DNA甲基化具有有限的长期影响.
- 跨代表观遗传效应,特别是母亲的影响,在塑造后代甲基化方面发挥着更重要的作用.
- 家长的环境史可能是人口对气候变化的抵抗力的一个关键因素.
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