相关实验视频

Updated: May 6, 2026

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Published on: August 24, 2017

液体线索:用ctDNA跟踪早期乳腺癌 - - 一个小小的回顾

Saumya Easaw¹, Johann Hsu¹, Nury Steuerwald²

¹Department of Solid Tumor Oncology and Investigational Therapeutics, Levine Cancer Institute, Atrium Health, Charlotte, NC, United States.

Frontiers in oncology

|September 12, 2025

概括

循环瘤DNA (ctDNA) 显示出治疗早期乳腺癌的前景. 这次审查涵盖了ctDNA.

科学领域:

在瘤学瘤学.
分子诊断学分子诊断学
基因组学就是基因组学.

背景情况:

非转移性乳腺癌的管理正在发展.
循环瘤DNA (ctDNA) 分析提供了新的见解.
目前的应用和ctDNA的未来潜力正在调查中.

研究的目的:

审查ctDNA在早期乳腺癌中的作用.
讨论ctDNA在早期检测,治疗反应和最小残留疾病 (MRD) 监测中的应用.
突出技术进步和涉及ctDNA的临床试验.

主要方法:

现有文献的小型综述.
对ctDNA测定技术进步的分析.
预期治疗干预试验的总结.

主要成果:

ctDNA在早期发现乳腺癌方面有潜在的应用.
ctDNA可以评估治疗反应,并监测MRD.
技术的改进提高了ctDNA测定的灵敏度.

结论:

ctDNA是非转移性乳腺癌管理的宝贵工具.
在临床实践中ctDNA的整合得到了正在进行的试验的支持.
未来的研究将进一步定义ctDNA在个性化乳腺癌护理中的作用.

关键词:

MRD - 最少残留疾病 - 最少残留疾病 ctDNActDNA是什么意思早期乳腺癌 (EBC) 早期乳腺癌个性化医疗是个性化的医疗.复发风险复发风险复发风险

更多相关视频

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

相关概念视频

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...