老年妇女的骨关节炎风险与平价之间的相关性:回顾性分析
Neelam Singh Raghuwanshi1, Neha Baraiya2, Sonendra Kumar Sharma3
1Department of Obstetrics and Gynaecology, SRVS Medical College, Shivpuri, Madhya Pradesh, India.
Journal of orthopaedic case reports
|September 12, 2025
概括
较高的平价,特别是大多平价,与印度老年妇女骨关节炎严重程度的增加有显著联系. 这一发现凸显了骨关节炎的潜在风险因素的平等性,为未来的查和预防策略提供了信息.
科学领域:
- 老年学是一门学科.
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 骨关节炎 (OA) 是老年妇女残疾的主要原因,受生物学和生活方式因素的影响.
- 生殖史,特别是平等,是OA发展的新兴潜在贡献者.
- 印度女性对OA风险的平等影响需要进一步探索.
研究的目的:
- 在绝经后的印度妇女中调查平价和骨关节炎严重程度之间的关联.
- 为了确定更高的平价是否是发展更严重的OA的风险因素.
主要方法:
- 在印度一家三级医院对234名绝经后妇女 (≥60岁) 进行了回顾性分析研究,这些妇女患有膝盖骨关节炎.
- 平价状态分为无双生,低 (1-3 个孩子),中等 (3-4 个孩子) 和大多生 (≥5 个孩子).
- 使用临床标准和放射证据 (Kellgren-Lawrence分级) 评估OA的严重程度;用Chi-square测试分析数据.
主要成果:
- 在较高的平价率和OA严重程度的增加之间发现了显著的正相关性 (P <0.01).
- 大多胞胎女性 (≥5个孩子) 呈现4级OA (24.0%) 的比例最高.
- 平均年龄为67.4±5.2岁,平均BMI为26.8±3.4kg/m2,并患有糖尿病 (33.3%) 和高血压 (43.6%) 等并发症.
结论:
- 较高的平价与老年妇女骨关节炎的风险和严重程度的增加有显著联系.
- 大多性可能是骨关节炎的独立风险因素.
- 建议在预防策略和OA早期查计划中考虑平价.
相关概念视频
Bone Disorders
5.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.1K
Relative Risk
2.0K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
Odds Ratio
1.7K
The odds ratio (OR) is a statistical measure used extensively in epidemiology and research to quantify the strength of association between exposure and outcome across different groups. Unlike relative risk, which compares the probabilities of an event occurring, the odds ratio compares the odds of an event occurring in the exposed group to the odds of it occurring in the unexposed group. The odds, in this context, are calculated as the probability of the event happening divided by the...
1.7K
Pharmacodynamics in Geriatric Patients: Effects of Age
190
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
190
Bias in Epidemiological Studies
1.3K
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
1.3K
Peripheral Artery Disease I: Introduction
320
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
320


