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硫化作为治疗糖尿病伤口的治疗剂:对炎症和纤维细胞灭的作用

Fusheng Zhao¹, Yuanyuan Li², Qunying Hu²

¹Department of Histology and Embryology, Mudanjiang Medical University, Mudanjiang, China.

Frontiers in immunology

|September 12, 2025

概括

硫化 (H2S) 治疗显著改善了大鼠糖尿病皮肤伤口愈合. 它通过抑制NLRP3炎症酶和NF-κB通路来减少炎症和纤维细胞核灭亡.

科学领域:

生物医学科学生物医学科学
伤口治愈研究研究伤口治愈研究
糖尿病并发症糖尿病并发症

背景情况:

慢性不愈合的伤口是糖尿病 (DM) 的严重并发症.
对于糖尿病伤口,有效的治疗选择有限.
硫化 (H2S) 在炎症条件下表现出保护作用.

研究的目的:

调查H2S在加快糖尿病皮肤伤口愈合方面的治疗潜力.
阐明H2S作用在糖尿病伤口修复中的潜在分子机制.

主要方法:

采用了一种因斯特佐托辛诱导的糖尿病大鼠模型.
鼠被用NaHS治疗,这是一个硫化供体.
评估了伤口愈合,组织学变化,炎症酶激活,纤维细胞灭以及NF-κB通路信号传递.

主要成果:

NaHS的使用使H2S水平正常化,并通过增强的原沉积促进了伤口愈合.
H2S治疗抑制了M1巨细胞的两极分化,并减少了促炎细胞因子 (TNF-α,IL-1β,IL-6).
NaHS抑制了NLRP3炎症酶激活,纤维细胞烧灭以及NF-κB通路信号传递.

结论:

硫化 (H2S) 有效地促进了糖尿病老鼠的皮肤伤口愈合.
H2S可以通过恢复H2S水平和抑制NLRP3炎症酶激活和纤维细胞烧灭来发挥其治疗作用.
H2S为治疗糖尿病皮肤伤口提供了一个有前途的治疗策略.

关键词:

通过NF-κB路径.在NLRP3炎症酶体中,NLRP3炎症糖尿病患者的皮肤伤口愈合愈合硫化是硫化的一种物质.热致灭症是什么?皮肤纤维细胞.

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Diabetic Foot Ulcer

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