相关实验视频

Updated: May 5, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

评估甘油三糖指数作为炎症性肠病风险的生物标志物:来自英国生物银行前性研究的见解

Manli Zhang¹, Feng Hu¹, Ling Miao¹

¹Department of Hepatology and Gastroenterology, The First Hospital of Jilin University, Changchun, China.

Frontiers in immunology

|September 12, 2025

概括

三甘油-葡萄糖 (TyG) 指数是胰岛素抵抗的标志物,与患上炎症性肠病 (IBD) 的风险较高有关,包括性结肠炎 (UC) 和克罗恩氏病.

科学领域:

代谢健康代谢健康
胃肠病学胃肠病学
流行病学流行病学

背景情况:

炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),是一个日益严重的全球健康挑战.
甘油三糖指数 (TyG) 是一种新兴的胰岛素耐药性指标.

研究的目的:

调查TyG指数与IBD发展风险之间的关联.
探索TyG指数在UC和CD预后中的作用.

主要方法:

分析了来自327,089名参与者的英国生物库数据.
从禁食甘油三和葡萄糖水平计算TyG指数,参与者分为四分位数.
利用了考克斯的比例危险模型,受限立方线,子组和调解分析,调整了许多共同变量.

主要成果:

较高的TyG指数与IBD风险增加有显著的关联.
每个单位的TyG增加与UC风险上升14.3%和CD风险上升13.8%相关.
与最低四分位数相比,最高的TyG四分位数显示CD风险增加了28.0%,UC风险增加了17.8%. 调解分析发现了几种血液标记物,有助于这种关联.

结论:

这项研究是第一个全面研究TyG指数与IBD风险和预后之间的关系,在一个大队列中.
结果表明,TyG指数与UC和CD发展风险之间存在显著的积极关联.
泰格指数可以作为IBD风险的独立预测标记.

关键词:

英国生物银行生物标志物生物标志物队列研究是一项队列研究.炎症性肠病是一种炎症性肠病.三甘油-葡萄糖指数指数

更多相关视频

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans

Published on: June 2, 2023

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

相关概念视频

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...