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在癌症免疫治疗中准瘤相关的巨细胞的进展

Wanqiu Xia¹, Xianghan Zhang², Yaru Wang¹

¹Department of Gynaecology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Frontiers in immunology

|September 12, 2025

概括

瘤相关巨细胞 (TAMs) 是癌症进展和免疫规避的关键驱动因素. 针对TAMs,特别是M2类表型,提供了一种有前途的策略,以提高癌症免疫疗法的疗效.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
癌症研究癌症研究

背景情况:

与瘤相关的巨细胞 (TAMs) 在瘤进展,免疫抑制和治疗耐药性方面发挥着关键作用.
TAMs表现出功能异质性,M2型TAMs促进瘤生长,M1型TAMs调解抗瘤免疫.

研究的目的:

审查TAM介导的免疫抑制机制.
总结目前用于癌症免疫治疗的TAM向策略.
探索将TAM向疗法与免疫检查点抑制剂相结合的潜力.

主要方法:

对TAM功能和治疗策略的文献综述.
对TAM介导的免疫抑制途径 (例如VEGF,TGF-β,PD-L1) 的分析.
对TAM向方法 (例如CD47/SIRPα阻断,CD40激动剂,PI3Kγ抑制剂) 的临床前发现的摘要.

主要成果:

TAMs分泌诸如VEGF,TGF-β和PD-L1之类的因素,有助于免疫抑制.
通过CD47/SIRPα轴阻塞,CD40激动剂和PI3Kγ抑制剂向TAM显示出临床前有希望的结果.
涉及TAM向疗法和免疫检查点抑制剂的组合方法正在出现.

结论:

在癌症免疫治疗中,TAM是关键的治疗点.
调节TAM表型和功能可以增强抗瘤免疫力.
优化涉及TAM的组合免疫疗法对于改善临床结果至关重要.

关键词:

与瘤相关的巨细胞.免疫检查点的检查点.免疫抑制是一种免疫抑制.免疫疗法免疫疗法治疗抵抗性的治疗.瘤微环境是一个微环境.

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