在T3N0M0阶段非小细胞肺癌中,单因子和多因子组之间的生存分析
İsmail Tombul1, Muhammet Sayan2, Şevki Mustafa Demiröz2
1Department of Thoracic Surgery, Ankara Training and Research Hospital, Ankara, Türkiye.
Turk gogus kalp damar cerrahisi dergisi
|September 12, 2025
概括
在接受手术治疗的非小细胞肺癌 (NSCLC) 患者中,多重T3因子显著恶化了生存率. 这一发现凸显了详细分期对于预测NSCLC结果的重要性.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 癌症预后 癌症预后
背景情况:
- 非小细胞肺癌 (NSCLC) 的分期对于治疗计划和预后至关重要.
- 第8版的瘤,结节,转移 (TNM) 阶段系统为分类NSCLC提供了一个框架.
- 患有T3N0M0阶段NSCLC的患者代表了一个异质的群体,预后不同.
研究的目的:
- 确定手术治疗的非小细胞肺癌患者的预后因素,分期为T3N0M0.0.
- 评估单个T3因子与多个T3因子对患者存活时间的影响.
- 确定这个患者队列的独立预后指标.
主要方法:
- 79名经过手术治疗的NSCLC患者的回顾性分析,病理阶段为T3N0M0.0.
- 患者被分为两组:单一T3因子 (n=56) 和多重T3因子 (n=23).
- 进行了生存分析,包括多变量分析,以确定预后因素.
主要成果:
- 单一T3因子患者的五年整体生存率为79.0%,多重T3因子患者为48.9% (p=0.02).
- 与多重T3因子组 (69.19个月) 相比,单T3因子组 (107.76个月) 的平均整体存活时间显著更长.
- 多变量分析确定了多个T3因子 (p=0.003) 和并发症 (p=0.004) 作为独立的不良预后因素.
结论:
- 多重T3因子的存在是手术治疗PT3非小细胞肺癌的显著不良预后指标.
- 同病症也在这些患者的预后中发挥着关键作用.
- 这些发现强调了详细的病理分期对于预测NSCLC的存活率的重要性.
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