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剖析肠道微生物群,血代谢物和膀癌之间的因果关系:一项双步门德尔随机化研究

Kai Che^1,2, Dong Qian³, Shuxia Cui⁴

¹Department of Urology The Affiliated Hospital of Qingdao University Qingdao China.

Health science reports

|September 12, 2025

概括

肠道微生物群 (GM) 影响膀癌 (BCa) 风险. 特定的细菌,如 Bacteroides dorei 和 Streptococcus 种类,以及代谢物,如 N-methylproline,显示因果关系,提供潜在的 BCa 治疗目标.

科学领域:

微生物组研究的研究.
遗传学是一个遗传学.
代谢学代谢学代谢学
在瘤学瘤学.

背景情况:

肠道微生物群 (GM) 与膀癌 (BCa) 有关,但因果关系和媒介仍然不清楚.
了解这些关系对于开发新的BCa预防和治疗策略至关重要.

研究的目的:

调查转基因生物和BCa之间的因果关系.
在GM-BCa轴中识别潜在的血代谢物介质.
探索BCa.的潜在治疗点.

主要方法:

利用了大规模的全基因组关联研究 (GWAS) 对转基因,血代谢物和BCa的总结统计数据.
进行双向门德尔随机化 (MR) 分析以评估因果关系.
采用两步MR方法来识别介导代谢物.

主要成果:

确定了三种肠道分类体 (Bacteroides dorei,Streptococcus物种,Bacteroides salyersiae) 和BCa之间的因果关系.
发现了五种与BCa和已识别的肠道类别同时相关的血代谢物.
确定N-甲基和X-19299调解了Bacteroides salyersiae和BCa之间的关联,分别解释了11.6%和28.56%的效果.
发现 Bacteroides dorei,Streptococcus 种类和 Bacteroides salyersiae 可能通过分别通过 2,3-dihydroxypyridine,N-palmitoyl-sphinganine 和 N-methylproline 影响 BCa.

结论:

在特定的肠道微生物群组成和膀癌之间建立了因果关系.
确定了关键的血代谢物,这些代谢物调解了肠道细菌对BCa的影响.
突出了基于肠道微生物群和代谢物相互作用的膀癌治疗的潜在新型治疗点.

关键词:

门德尔的随机化膀癌:膀癌是一种癌症.我们的肠道微生物群.血代谢产物中的血代谢产物

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