电可以缓解症状,并识别潜在的微生物生物标志物在患有便秘占主导地位的刺激性肠综合征的患者
Kiangyada Yaklai1, Chanon Kunasol2,3, Kanokphong Suparan4
1Sriphat Medical Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
电针 (EA) 通过调节肠-大脑轴和微生物群来改善便秘性易怒肠综合征 (IBS-C). 细菌Senegalimassilia可以预测接受EA的IBS-C患者的治疗反应.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 神经科学是一个神经科学.
背景情况:
- 便秘性刺激性肠综合征 (IBS-C) 是一种慢性疾病,影响生活质量,没有确定的治疗方法.
- 电针 (EA) 对IBS-C和肠-大脑轴调节显示出有效性,但机制尚不清楚.
研究的目的:
- 在IBS-C患者中调查肠-大脑-微生物群轴的改变.
- 确定EA相关的微生物变化和反应者.
- 探索EA治疗的潜在微生物生物标志物.
主要方法:
- 横截面研究比较了16名IBS-C患者和16名对照人群的基线微生物群.
- 在一个月内接受9次EA治疗的16名IBS-C患者的长度研究.
- 评估肠道微生物群和治疗前和治疗后的临床结果,并进行一个月的随访.
主要成果:
- 与对照组相比,IBS-C患者表现出显著的肠道失调 (改变β多样性).
- EA治疗改善了临床结果,并使肠道功能障碍正常化,具有持续的效果.
- 肠道细菌Senegalimassilia与症状改善有积极的关联,表明作为预测生物标志物的潜力.
结论:
- 这些发现支持EA集成到IBS-C管理中.
- 塞内加利马西利亚是一种潜在的微生物生物标志物,用于预测IBS-C.的EA治疗反应.
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