Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
Cancer Vaccines01:30

Cancer Vaccines

976
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
976
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.7K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Importance of the delivery route for the tolerability and efficacy of immunomodulatory agents for lung cancer.

Scientific reports·2026
Same author

Assessment of NK cell cytotoxicity induced by IL-15 based immunotherapy against cancer cells.

Methods in cell biology·2026
Same author

Inborn errors of immunity affecting the MHC class I pathway for antigen presentation.

Journal of human immunity·2026
Same author

Foundation models for brain imaging: A systematic review.

NeuroImage·2026
Same author

Targeting the energy metabolism of melanoma cells: FX-11 acts as a mitochondrial uncoupler.

European journal of pharmacology·2026
Same author

Identification of Circulating MiR-4651 as Novel Biomarker for Metabolic Dysfunction-Associated Steatotic Liver Disease.

Gastro hep advances·2026

相关实验视频

Updated: Jan 18, 2026

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
13:19

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

Published on: April 26, 2024

3.8K

导向补充激活作为HER2-乳腺癌的新型免疫治疗方法.

Carole Seguin-Devaux1, Bianca Brandus1, Jean-Marc Plesseria1

  • 1Department of Infection and Immunity, Luxembourg Institute of Health, Esch sur Alzette, Luxembourg.

ImmunoTargets and therapy
|September 12, 2025
PubMed
概括

新型免疫疗法复合物 (CoMiX) 有效地激活瘤细胞上的补充通路,为抗体提供了有前途的替代品. 这些复合物表现出强大的抗瘤活性,即使对抗耐药癌症,这表明了组合疗法的新方法.

关键词:
在 NK 细胞中,NK 细胞是 NK 细胞.补充依赖的细胞毒性.免疫疗法 免疫疗法发酵细胞的形成 发酵细胞的形成异种移植模型模型

更多相关视频

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.0K
High-Content Screening Assay for the Identification of Antibody-Dependent Cellular Cytotoxicity Modifying Compounds
13:59

High-Content Screening Assay for the Identification of Antibody-Dependent Cellular Cytotoxicity Modifying Compounds

Published on: August 18, 2023

2.7K

相关实验视频

Last Updated: Jan 18, 2026

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
13:19

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

Published on: April 26, 2024

3.8K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.0K
High-Content Screening Assay for the Identification of Antibody-Dependent Cellular Cytotoxicity Modifying Compounds
13:59

High-Content Screening Assay for the Identification of Antibody-Dependent Cellular Cytotoxicity Modifying Compounds

Published on: August 18, 2023

2.7K

科学领域:

  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.
  • 生物技术是生物技术.

背景情况:

  • 通过补充激活向瘤细胞是消除癌症的关键策略.
  • 多重体免疫疗法复合物 (CoMiX) 已经开发出来,可以选择性地激活癌细胞上的补充通路.

研究的目的:

  • 在HER2表达瘤细胞上产生和评估可刺激替代途径 (CoMiX-FHR4) 或经典途径 (CoMiX-Fc) 的CoMiX.
  • 为了比较CoMiX的疗效与现有的治疗抗体,如trastuzumab和pertuzumab.

主要方法:

  • 使用C4结合蛋白支架构建了CoMiX,该支架结合了与H因子相关的蛋白4 (FHR4) 或具有抗HER2VHH抗体的Fc二极体.
  • 在体外测试中评估了C3b/C5b9沉积,补剂依赖性细胞毒性 (CDC),NK细胞激活和巨细胞化.
  • 在体内研究评估了裸体小鼠在人类BT474瘤异种移植中的治疗疗效.

主要成果:

  • 与特拉斯图祖马布和珀图祖马布相比,CoMiX-FHR4变种在BT474细胞上显示出更高的C3b/C5b9沉积和CDC.
  • 所有的CoMiX都诱导了瘤细胞死亡和细胞分裂;CoMiX-Fc也激活了NK细胞.
  • 在体内,CoMiX-FHR4显示出抗瘤效果,而CoMiX-VHH(P) /Fc与珀图祖马布的疗效相匹配.
  • CoMiX的组合增强了抗瘤活性和NK细胞透.
  • CoMiX-FHR4被证明对抗抗斯拉图祖马布耐药的异种移植有效,延缓瘤生长并增加NK细胞透.

结论:

  • 通过CoMiX引导补充激活代表了治疗抗体的可行替代方案.
  • CoMiX具有组合疗法的潜力,特别是在对标准治疗有耐药性的情况下.
  • 这些发现为开发针对HER2表达瘤的先进免疫疗法开辟了新的途径.