全球DNA甲基化和认知障碍:来自北印度哈里亚纳州的一项基于人口的研究
Kevingu Khate1, Vineet Chaudhary1, Debashis Bhattacharjee1
1Department of Anthropology, University of Delhi, Delhi, 110007 India.
Indian journal of clinical biochemistry : IJCB
|September 12, 2025
概括
北印度成年人的认知障碍与较低的全球DNA甲基化有关. 维生素B12的充足可能有助于改善认知障碍患者的甲基化水平.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 神经科学是一个神经科学.
- 营养科学 营养科学
背景情况:
- 包括DNA甲基化在内的表观遗传修饰越来越多地与认知障碍有关.
- 环境因素和营养状况可以显著影响DNA甲基化和认知功能之间的关系.
研究的目的:
- 研究全球DNA甲基化水平与北印度成人认知障碍之间的关联.
- 探索微量营养素状况,特别是叶酸和维生素B12在这种关系中的作用.
主要方法:
- 在哈里亚纳邦帕尔瓦尔的614名成年人 (30-79岁) 的横截面研究.
- 使用迷你精神状态检查 (MMSE) 评估认知障碍.
- 全球DNA甲基化水平 (5mC) 通过ELISA测量;叶酸,维生素B12和同类蛋白通过化学发光.
主要成果:
- 与对照组相比,轻度和中度/重度认知障碍患者的全球DNA甲基化水平 (5mC) 中位数显著降低.
- 全球DNA甲基化水平的下四分位数与认知障碍风险显著增加有关.
- 维生素B12状态,而不是叶酸,似乎在认知障碍病例中调解了全球DNA低甲基化.
结论:
- 全球DNA低甲基化与研究的北印度人口的认知障碍有关.
- 维生素B12的充足程度可能在改善认知障碍患者的甲基化水平方面发挥作用.
- 开发特定于人群的认知障碍表观遗传标记是有必要的.
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