维生素D与台湾患者的COVID-19感染和死亡率之间的关联
Ching-Ching Sheng1,2, Shuan-Yi Su1, Ying Liang1
1Department of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Journal of the Chinese Medical Association : JCMA
|September 12, 2025
概括
维生素D缺乏没有影响COVID-19感染风险,但在症状患者中显著增加死亡风险. 保持足够的维生素D至关重要,特别是对于老年人来说,以减少COVID-19死亡率.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 维生素D因其在免疫系统调节中的作用而闻名.
- 新出现的证据表明,维生素D状态与COVID-19结果之间存在潜在联系.
- 这项研究调查了血清维生素D水平与台湾COVID-19感染和死亡率之间的关联.
研究的目的:
- 检查血清25-基维生素D (25(OH) D) 水平与COVID-19感染风险之间的关系.
- 评估维生素D状态对COVID-19相关死亡率的影响.
- 为了确定维生素D缺乏是否会在特定年龄段带来更大的风险.
主要方法:
- 使用了回顾性队列研究设计.
- 包括在2020年至2023年期间接受COVID-19RT-PCR测试的症状患者.
- 血清25(OH) D水平被分类为不足 (<20 ng/mL),不足 (20-30 ng/mL) 或足够 (≥30 ng/mL),后勤回归分析了与感染和死亡的关联,控制了混因素.
主要成果:
- 在481名参与者中,有19.96%的人检测出COVID-19阳性. 维生素D水平与COVID-19感染没有显著的关联 (OR = 1.00,p = 0.687).
- 维生素D缺乏与COVID-19死亡率增加的风险显著相关 (OR = 10.68,p = 0.035).
- 老年人 (65-74岁) 的死亡风险明显高于年轻人 (19-44岁) 的死亡风险.
结论:
- 血清维生素D水平与对COVID-19感染的易感性无关.
- 维生素D缺乏是COVID-19患者,特别是老年人死亡率增加的重要危险因素.
- 对于高风险人群来说,建议保持足够的维生素D水平,以潜在地减轻严重的COVID-19结果.
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