[丸聚酸对男性不孕症患者的精子参数和精子DNA碎片化指数的影响]
I Gamidov S1,2, Yu Popova A1,2, V Shatylko T1,2
1National Medical Research Center of Obstetrics, Gynecology and Perinatology named after V.I. Kulakov of the Ministry of Health of Russia, Moscow, Russia.
Urologiia (Moscow, Russia : 1999)
|September 12, 2025
概括
在男性不孕症患者中,Testiwell治疗显著改善了精子参数,并减少了DNA碎片化. 这种牛丸多疗法为男性不孕症提供了一个新的选择,包括涉及辅助生殖的病例.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 生物技术是生物技术.
背景情况:
- 异形性男性不孕症影响了大量寻求生育治疗的夫妇.
- 精子DNA碎片化是影响男性生育能力和辅助生殖结果的关键因素.
研究的目的:
- 为了评估Testiwell的疗效,一种来自牛丸多的药物,在改善精子参数和减少精子DNA碎片化方面,在患有异常不孕症的男性中.
- 探索Testiwell在增强精子生成方面的潜在作用机制.
主要方法:
- 一项前性研究涉及100名不育的男性,他们接受了Testiwell肌肉内注射10周的治疗.
- 在治疗前和治疗后评估标准精子参数 (WHO标准) 和精子DNA碎片化指数 (TUNEL方法).
- 用适当的统计分析来确定显著性.
主要成果:
- 丸治疗导致精子形态 (p<0.001) 和形态正常精子度 (p=0.048) 的显著改善.
- 观察到精子DNA碎片化指数的显著下降 (p<0.001),以及小动物精子症的减少 (p=0.0047) 和DNA碎片化增加 (p=0.0013).
- 具体的改善包括142%的精子度增加在精子的男性和77%的运动增加在精子的男性.
结论:
- Testiwell有效地提高了精子的定量和定性参数,包括形态和DNA完整性.
- 潜在的机制包括调节蛋白质激发,减少细胞灭绝和调节精子成熟期间的免疫反应.
- 特斯蒂韦尔在治疗各种形式的男性不孕症和改善辅助生殖技术的结果方面表现有前途.
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