维护AVELUMAB对晚期泌尿腺癌的影响:现实世界多中心研究
Noritaka Ishii1,2, Yuya Sekine3, Masanao Shinohara4
1Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Cancer medicine
|September 12, 2025
概括
与单独的化疗相比,avelumab的维持治疗显著改善了晚期泌尿腺癌患者的整体存活率. 这项现实研究发现,接受阿维卢马布治疗的患者的治疗结果更好,无论治疗的切换时间如何.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 尿癌研究 尿癌研究
背景情况:
- 晚期泌尿腺癌 (UC) 治疗传统上依赖于基于的化疗.
- 维持治疗策略对于改善UC的长期结果至关重要.
- 现实世界的数据对于补充临床试验结果至关重要.
研究的目的:
- 为了比较avelumab维持疗法的瘤结果与晚期UC患者的传统一线化疗.
- 在现实实践中评估整体存活率 (OS).
- 评估治疗策略对患者存活率的影响.
主要方法:
- 在2004年3月至2024年9月期间接受治疗的晚期UC患者的回顾性评估.
- 对接受第一线化疗而没有阿维卢马布 (化疗组) 和阿维卢马布维持疗法 (阿维卢马布组) 的患者进行比较.
- 通过治疗切换时间对OS进行分层 (在周期4进行标准切换,在周期2-3进行早期切换).
主要成果:
- 在标准切换队列中,AVELUMAB (70个月) 的中位数寿命显著超过化疗 (26个月;p=0.015).
- 在早期切换队列中,AVELUMAB的中位寿命显著长 (33个月) 比化疗 (13个月;p=0.002).
- 阿维卢马布的使用与OS风险降低63%有关 (危险比,0.37;p<0.001).
结论:
- 在晚期UC患者中,Avelumab维持疗法显示改善了瘤治疗结果.
- 在不同的治疗切换时间 (循环2-3和≥4) 中观察到益处.
- 虽然有希望,但应该考虑由于追溯设计而造成的剩余混.
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