Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Transformations of Functions III

Transformations of Functions III

Transformations modify the graphical representation of a function without changing its fundamental form. One common transformation is reflection, which flips the graph across a designated axis. When the vertical coordinates of all points are multiplied by the negative one, the entire graph is mirrored over the horizontal axis. This transformation reverses the vertical orientation of peaks and troughs, akin to signal inversion in electrical systems, where a waveform is flipped, but the timing of...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Differential COVID-19 Outcomes Across Lysosomal Disorders.

medRxiv : the preprint server for health sciences·2026

Same author

The Cell Ontology in the age of single-cell omics.

Scientific data·2026

Same author

Population differences in wearable device wear time: Rescuing data to address biases and advance health equity.

medRxiv : the preprint server for health sciences·2026

Same author

Wavelet-Based Pattern ERG Biomarkers Outperform Temporal Amplitude Measures for Functional Stratification in Optic Nerve Disease.

Translational vision science & technology·2026

Same author

Governing real-world health data as a public utility.

Science (New York, N.Y.)·2026

Same author

A custom phenotypic profile for Fanconi anemia: Addressing gaps in existing disease annotations.

medRxiv : the preprint server for health sciences·2026

Search research articles

相关实验视频

Updated: Jun 21, 2026

Multifocal Electroretinograms

Multifocal Electroretinograms

Published on: December 4, 2011

在模式电网红学中,多维量化斑点活动,使用离散波形变换.

Yousif J Shwetar^1,2, Melissa A Haendel^3,4

¹Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, USA.

Translational vision science & technology

|September 12, 2025

概括

离散波纹转换 (DWT) 功能为遗传性视网膜疾病中的黄斑功能提供了新的定量生物标志物. 在临床试验中,sim2-D6-2指数显示出对监测疾病进展和治疗评估的前景.

更多相关视频

Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats

Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats

Published on: July 1, 2016

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Published on: May 26, 2023

相关实验视频

Last Updated: Jun 21, 2026

Multifocal Electroretinograms

Multifocal Electroretinograms

Published on: December 4, 2011

Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats

Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats

Published on: July 1, 2016

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Published on: May 26, 2023

科学领域:

眼科医生眼科眼科
生物医学工程生物医学工程
信号处理信号处理

背景情况:

黄斑占主导地位的遗传视网膜疾病 (mpIRDs) 影响形光受体,需要可靠的生物标志物进行监测.
图案电网膜学 (PERG) 评估黄斑功能,但定量特征提取仍然是一个需要进步的领域.

研究的目的:

评估离散波波变换 (DWT) 特性作为黄斑功能量的生物标志物.
评估这些DWT特征在斑点主导性遗传视网膜疾病 (mpIRDs) 的模式电视网膜学 (PERG) 背景下的实用性.

主要方法:

分析了使用DWT的123名参与者的486个PERG记录.
选了20个母波,保留了6个用于特征生成,随后进行了清洁和关联修剪,以获得141个特征.
使用 sym2 波段利用反向DWT信号重建来识别保留关键 PERG 峰值 (N35,P50,N95) 的时间频率指数.

主要成果:

该sym2-D6-2指数 (38-75毫秒,13-27赫兹) 成为最高的区分特征,与临床黄斑标志物P50-N35 (rcorr = 0.95) 呈现强烈的相关性.
与P50-N35相比,这种DWT衍生指数显示出优越的组分离,曲线下的诊断面积更高 (0.875比0.835) 和更大的效果大小 (res = 0.644比0.576).
Sym2-D6-2提供了更紧密的,不重叠的组分布,表明了增强的诊断能力.

结论:

来自DWT的时间频率特征,特别是sym2-D6-2,作为斑点功能强大的多维生物标志物.
这些定量终点显示了监测疾病进展和评估mpIRD中的治疗干预措施的巨大潜力.
sym2-D6-2指数为斑点功能提供了一个客观的指标,适用于mpIRD临床试验中的定量终点.