高敏感性C-反应蛋白水平与代谢功能障碍相关的脂肪性肝病和肝纤维化风险之间的关联:基于NHANES数据的研究
Chaolong Xu1, Kai Wang1, Zhiming Peng1
1Department of Hepatobiliary Surgery, People's Hospital of Yicheng City, Yicheng, China.
概括
高敏感性C反应蛋白 (hs-CRP) 水平的升高显著增加了患有与代谢功能障碍相关的脂肪性肝病 (MASLD) 和肝纤维化 (LF) 的风险. Hs-CRP可以作为早期检测和管理的有价值的生物标志物.
科学领域:
- 生物标志物和诊断方法
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 高灵敏度C反应蛋白 (hs-CRP) 是一种已知的炎症生物标志物.
- 炎症与各种代谢障碍有关,包括肝脏疾病.
研究的目的:
- 研究hs-CRP水平与与代谢功能障碍相关的脂肪性肝病 (MASLD) 风险之间的关联.
- 研究hs-CRP水平与肝纤维化 (LF) 风险之间的相关性.
主要方法:
- 分析了2017-2020年国家健康和营养检查调查的2787名参与者的数据.
- 暂时弹性图用于评估肝脏脂肪和纤维化.
- 后勤回归模型用于评估hs-CRP水平与MASLD和LF风险相对应.
主要成果:
- 与hs-CRP≤3 mg/L的个体相比,hs-CRP水平>3 mg/L的个体显示MASLD的几率明显增加.
- 对于MASLD的几率比率在较高的hs-CRP类别 (3.01-6,6.01-10,≥10.01 mg/L) 中增加.
- 模型验证证实了hs-CRP升高与MASLD和LF风险增加之间的显著关联.
结论:
- 升高的hs-CRP水平与患MASLD和LF的风险更高密切相关.
- Hs-CRP显示出作为预测生物标志物的潜力,用于识别患有MASLD和相关肝纤维化风险的个体.
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