由动脉瘤部的流量转移支架引起的血液变化,大脑循环中的血液变化
Osman Ergin1, Ali Bahadir Olcay1,2, Alperen Elek3
1Department of Mechanical Engineering, Yeditepe University, Istanbul, Turkey.
Neuroradiology
|September 12, 2025
概括
在内动脉瘤中植入流量转移支架 (FDS) 显著增加支架支架之间的剪切应力和张力率. 这些升高的力与动脉瘤体积相关,突出显示了潜在的血液动力学风险.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 流体动力学 流体动力学
背景情况:
- 内动脉瘤具有显著的中风风险.
- 流量转移支架 (FDS) 用于通过重定向血流来治疗动脉瘤.
- 了解FDS的血液动力学影响对于优化治疗结果至关重要.
研究的目的:
- 研究FDS植入物对内动脉瘤的血液动力学影响.
- 量化剪切应力和剪切应力率在FDS后动脉瘤部的变化.
- 为了将这些血液动力学变化与动脉瘤特征相关联.
主要方法:
- 从数字减法血管学 (DSA) 数据中重建了患者特有的动脉几何形状.
- 计算流体动力学 (CFD) 模拟在48和64线FDS配置的模型上进行.
- 在FDS植入之前和之后,在支架支架之间分析了剪切应力和拉伸率.
主要成果:
- 植入前,剪切应力和应变率低于值.
- 植入后,支架支架之间的剪切应力和张力率显著增加,一些超过生理值.
- 48和64线FDS模型都显示出与非支架模型相比,剪切力增加,支架设计之间没有显著差异.
- 动脉瘤体积与最大和平均剪切力正相关.
结论:
- 植入FDS始终会在动脉瘤部引发超生理学剪切应力和剪切应力率.
- 这些诱导的剪切力与动脉瘤体积有显著的相关性,这表明动脉瘤进展或稳定的潜在机制.
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