休息状态功能性MRI活动和炎症性肠病中的连接性:系统性审查
Maria Veatriki Christodoulou1, George A Alexiou2, Marios Lampros2
1Department of Radiology, Faculty of Medicine, University of Ioannina, Ioannina, Greece. maria.veatriki@gmail.com.
休息状态的功能性MRI揭示了炎症性肠病 (IBD) 中明显的脑活动模式. 性结肠炎 (UC) 患者表现出记忆和运动区域的活性降低,而克罗恩病患者则表现出记忆和运动区域的活性降低.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 医疗成像医学成像
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),扩展到胃肠道之外,影响中枢神经系统 (CNS).
- 休息状态功能性MRI (rs-fMRI) 是研究大脑活动和功能连接的宝贵工具.
- 了解中枢神经系统在IBD中的参与对于整体的患者方法至关重要.
研究的目的:
- 系统地审查和评估IBD患者的休息状态功能性MRI (rs-fMRI) 发现.
- 将IBD患者的rs-fMRI变化与健康对照组的改变进行比较.
- 确定克罗恩病 (CD) 和性结肠炎 (UC) 之间大脑活动和连接的潜在差异.
主要方法:
- 在PubMed/MEDLINE和SCOPUS数据库中的系统文献搜索.
- 包括关注神经学无症状IBD患者的观察性rs-fMRI研究.
- 基于rs-fMRI分析技术的发现的描述性总结,由于方法异质性.
主要成果:
- 包括27项研究,揭示了不同的rs-fMRI发现.
- 性结肠炎 (UC) 患者表现出海马活动减少和大脑小脑/视觉网络连接的改变,影响记忆和运动控制.
- 克罗恩氏病 (CD) 患者在前带皮质和额头区域的活性增加,感官和认知网络的连接性发生变化.
- 无论是CD还是UC,都表现出默认模式,突出和小脑网络的破坏,这些网络与情绪,疼痛和压力调节有关.
结论:
- 独特的rs-fMRI模式区分UC和CD,UC与记忆/运动区域的活动减少有关,CD与情绪/认知区域的活动增加有关.
- 关键大脑网络的共同干扰突显了IBD对大脑功能的普遍影响.
- 这些发现强调了大脑-肠轴在调解与IBD相关的情绪和感官障碍方面的重要性.
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