巨细胞动脉炎中的舌腔亡:基于病例的综述
Noelia Cabaleiro-Raña1, Carmen Álvarez-Reguera2, Evelin Cecilia Cervantes Pérez2
1Rheumatology Department, University Hospital Complex of Pontevedra, Pontevedra, Spain. noeliamedicalcr@gmail.com.
Rheumatology international
|September 12, 2025
概括
巨细胞动脉炎 (GCA) 可以导致罕见的舌腔亡,即使没有典型的症状. 早期诊断和使用托西利祖马布等药物的治疗对于治愈和预防并发症至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 血管医学 血管医学
- 内部医学 内部医学
背景情况:
- 舌腔亡是巨细胞动脉炎 (GCA) 的罕见但严重的并发症.
- 诊断可能具有挑战性,特别是缺乏经典GCA症状的非典型表现.
- 这一案例突出了一个年轻的患者,患有吸烟和偏头痛等危险因素.
研究的目的:
- 呈现一种非典型表现的患者在GCA后的语言亡病例.
- 审查现有的关于GCA语言性亡的文献.
- 评估托西利祖马布在管理与GCA相关的语言亡中的作用.
主要方法:
- 一个59岁的女性的病例报告,患有严重的舌头疼痛和部不适.
- 由于在降低类固醇剂量后症状恶化,开始使用葡萄糖皮质激素治疗,其次是托西利祖马布.
- 关于GCA中55例语言亡病例的文献综述.
主要成果:
- 患者在开始服用托西利祖马布后显着减少了舌头胀和逐渐愈合.
- 审查显示患者平均年龄为77.8岁,女性占主导地位,高血压是常见的危险因素.
- 32.7%的复查病例呈现语言性亡作为最初的GCA表现;13名患者除了葡萄皮质皮质激素外还需要额外的免疫抑制剂.
结论:
- 在语言亡的差异诊断中应考虑GCA,即使是在年轻的患者或具有非典型症状的患者中.
- 早期检测和及时治疗对于防止不可逆转的损伤至关重要.
- 托西利祖马布显示承诺作为一个有效的治疗选择,GCA相关的语言亡耐药的葡萄糖皮质类药物.
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