华西通比公式对湿热影响Pi () 模式的勃起功能障碍的影响:多中心,随机,受控的非劣等性试验
He-de Zou1,2, Pei-Hai Zhang3,4, Wen-Kang Chen1,5
1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Chinese journal of integrative medicine
|September 12, 2025
概括
华西通比配方 (HTF) 证明,在治疗湿热影响Pi模式的勃起功能障碍 (ED) 时,其疗效与西尔德纳菲尔无差. 这种传统的中医药提供持续的症状缓解和持久的效果,可能通过肠道微生物群调节.
科学领域:
- 综合医学是一个整体的医学.
- 胃肠病学 胃肠病学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 湿热影响Pi模式的勃起功能障碍 (ED) 是传统中医学的特定诊断.
- 肠道微生物群失调症越来越多地与各种健康状况有关,包括ED.
研究的目的:
- 评估华西通比配方 (HTF) 对于湿热影响Pi模式的ED的疗效和安全性.
- 通过分析其对肠道微生物群的影响来探索HTF的潜在机制.
主要方法:
- 一个多中心的,随机的,并行,正控,非劣势性试验,涉及162名ED患者.
- 在8周的治疗和8周的随访期间,HTF颗粒与西尔代纳菲尔酸盐的比较.
- 使用有效率,IIEF-5,EQS和CMS分数评估疗效;通过16SrDNA测序进行肠道微生物群分析.
主要成果:
- 与西尔代纳菲尔相比,HTF显示出非劣质的疗效.
- 在随访期间,HTF治疗导致IIEF-5和EQS得分持续改善,并降低了CMS得分.
- HTF调节了肠道微生物群,增加了Lachnospiraceae和Blautia,并改变了其他特定细菌和微生物功能的丰度.
结论:
- HTF是一种可行的治疗选择,用于湿热影响Pi模式的ED,提供与西尔代纳菲尔相似的疗效.
- HTF提供持续的症状缓解和治疗后持续的治疗效果.
- 肠道微生物群调节是HTF在ED治疗效果的潜在机制.
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