生物基智能响应水凝在胰岛素输送中的应用和发展前景
Huijuan Su1, Xiaolian Chen1, Dongyi Huang1
1School of Pharmacy, Guangxi Medical University, Nanning, 530000, Guangxi, PR China.
Drug delivery and translational research
|September 12, 2025
概括
智能水凝为糖尿病管理提供先进的胰岛素输送,改善释放控制和患者安全. 本综述探讨了克服临床应用挑战的创新和解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 糖尿病管理 糖尿病管理
背景情况:
- 糖尿病的流行需要改进的胰岛素输送方法,而不仅仅是传统的注射.
- 皮下和静脉注射胰岛素面临的挑战包括频繁的注射,胰岛素耐药性和低血糖风险.
研究的目的:
- 审查基于水凝的胰岛素输送系统的进展.
- 专注于具有控制释放机制和复合系统的智能水凝.
- 探索克服临床应用中的翻译挑战的策略.
主要方法:
- 关于水凝特性,交叉连接和聚合物组成的最新文献的综述.
- 综合系统的分析包括纳米粒子,脂质体和微针.
- 探索生物灵感设计和机器学习以进行优化.
主要成果:
- 智能水凝通过pH,葡萄糖和温度反应来实现精确的胰岛素释放控制.
- 复合系统增强胰岛素负载能力和释放稳定性.
- 生物灵感设计和机器学习显示出优化水凝特性和生产的潜力.
结论:
- 水凝对于先进的胰岛素输送具有显著的潜力,提供了更好的安全性和有效性.
- 解决存储,规模生产和监管途径方面的挑战对于临床翻译至关重要.
- 优化的水凝胰岛素输送系统可以为糖尿病患者提供更好的治疗选择.
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