上呼吸道微生物群,粘膜功能和支气管切除的临床结果:来自EMBARC-BRIDGE研究的数据
Hayoung Choi1, Hollian Richardson2, Chandani Hennayake2
1Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea.
支气管病患者的上呼吸道微生物组组成与疾病的严重程度和恶化有关. 鼻喉功能失调症,特别是 Pseudomonas,与更糟糕的临床结果和更严重的呼吸道症状相关.
科学领域:
- 微生物学 微生物学
- 肺部病理学 肺部病理学
- 遗传学 遗传学 是一个
背景情况:
- 感染显著推动支气管病变的疾病进展.
- 上呼吸道微生物组影响下呼吸道微生物组的组成.
- 了解这种关系对于管理支气管切除症至关重要.
研究的目的:
- 调查上呼吸道微生物群,粘膜细胞功能和支气管切除症患者的临床结果之间的关联.
- 确定与疾病严重程度和恶化相关的特定微生物模式.
- 评估上呼吸道微生物群的稳定性.
主要方法:
- 收集了来自欧洲五个中心的344名支气管切除症患者的鼻抽样.
- 分析了微生物组的组成,α-多样性 (Chao1) 和β-多样性 (Bray-Curtis).
- 使用随机森林分析,并根据病原性种群的丰富性定义了失生症 (Pseudomonas,Haemophilus,Staphylococcus).
主要成果:
- α-多样性根据疾病严重程度显著不同 (P=0.002).
- 显著的微生物组特征与疾病严重程度和严重恶化有关 (分别P=0.021和P=0.001).
- Pseudomonas 丰富度与严重的支气管切开,恶化和唾液相关 Pseudomonas aeruginosa 的生长;与更糟糕的症状和结果相关的失生症.
结论:
- 上呼吸道微生物组的组成与支气管切除症的严重程度有显著的关联.
- 鼻功能失调是更严重的临床结果和恶化的预测因素.
- 微生物组概况在基线和1年随访期间表现出相对稳定性.
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