在查结肠镜检查后,肠道微生物群的重新填充
Yezaz A Ghouri1, Aaron C Ericsson2, Jennifer M Anderson3
1Division of Gastroenterology and Hepatology, School of Medicine, University of Missouri, Columbia, Missouri, United States of America.
PloS one
|September 12, 2025
概括
饮食摄入量影响肠道微生物组在结肠镜检查后的重新填充. 手术后增加的能量和纤维摄入量有助于恢复微生物平衡,突出了营养在肠道健康中的作用.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 肠道微生物组在健康和疾病中起着至关重要的作用.
- 结肠镜的准备和手术本身可以改变肠道微生物群.
- 饮食摄入量和结肠镜检查后微生物组恢复之间的关系尚不清楚.
研究的目的:
- 为了研究结肠镜检查后肠道微生物群的早期重新繁殖模式.
- 为了将这些重新定居模式与同时自由生活的饮食摄入量相关联.
- 了解饮食变化对微生物组恢复后肠道准备对饮食变化的影响.
主要方法:
- 招募了15名健康成年人接受查结肠镜检查.
- 在基线和结肠镜后 (第0,1,2,4,7,10,13天) 收集了3天的食物记录.
- 在结肠镜前和结肠镜后 (第3,5,8,11,14天) 获得的便样本,用于16S rRNA amplicon测序.
主要成果:
- 试验对象在结肠镜检查后5天内增加了每日总能量摄入量.
- 结肠镜检查当天纤维摄入量下降,但随后恢复到基线水平.
- 肠道微生物群β多样性的显著变化和某些类型 (例如,Bacillota) 的枯竭在结肠镜检查后被观察到,在第5天恢复.
结论:
- 结肠镜显著改变肠道微生物组的组成和多样性.
- 微生物组重新定居的时间与手术后的饮食摄入量变化密切相关.
- 适当的营养,特别是纤维摄入量,对于在结肠镜检查后恢复健康的肠道微生物群至关重要.
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