在一期临床诊所中建立临床IDS药剂师角色
Felecity Estrella1, Julia Lewin1, Anneliese Schuessler1
1IDS Pharmacy Department, Fred Hutchinson Cancer Center, UW Medicine, Seattle, WA, USA.
概括
将临床药剂师纳入早期瘤学试验可以提高患者的安全性和试验管理. 他们在药物管理和药物相互作用方面的专业知识对于复杂的早期临床研究至关重要.
科学领域:
- 在瘤学瘤学.
- 临床药房 临床药房
- 药物治疗 药物治疗
背景情况:
- 第1期瘤学临床试验是复杂的,患者的安全是首要任务.
- 临床药剂师在药物治疗和以患者为中心的护理方面拥有专业知识,这对于管理试验中的药物治疗方案和相互作用至关重要.
- 临床药剂师持续融入临床试验团队仍然是一个挑战.
研究的目的:
- 评估Fred Hutch第1期临床试验计划中的嵌入式临床研究药物服务 (IDS) 药剂师的利用,干预类型,时间分配和查询来源.
- 评估药剂师整合对早期瘤学试验管理和安全性的影响.
主要方法:
- 进行了回顾性审查,将试点阶段 (2021年4月至2022年4月) 与后续阶段 (2023年4月至9月) 相比较.
- 收集的数据包括干预类型,频率,持续时间和通信方式.
- 用描述性分析来评估药剂师的活动和影响.
主要成果:
- 在试点阶段共记录了311项干预措施,同时药物评估 (77%) 和药物信息 (16%) 是主要的.
- 在6个月的随访中,记录了302次干预,显示出对药剂师服务的依赖性增加,同时服用药物的审查仍然很高 (83%).
- 超过85%的询问来自研究协调员和护士,数字通信工具提高了工作流的效率.
结论:
- 临床IDS药剂师的整合显著提高了第一阶段瘤学试验的管理,维护高安全性和合规标准.
- 药剂师的贡献对于支持早期临床试验研究至关重要.
- 有机会扩大临床药剂师的作用,以应对临床试验日益复杂的问题.
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