十二周的富含酸盐的甜菜提取物补充剂改善了下肢血管功能和绝经后妇女的血清血管生成潜力
Thiago Silveira Alvares1, Vivian Pinheiro1, David N Proctor2
1Multidisciplinary Center UFRJ-Macaé, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
American journal of physiology. Heart and circulatory physiology
|September 12, 2025
概括
饮食中酸盐补充与甜菜提取物改善了绝经后妇女的血管功能. 这项为期12周的干预措施改善了血液流动和血管健康,可能降低了心血管疾病风险.
科学领域:
- 心血管科学 心血管科学
- 营养科学 营养科学
- 老年学是指老年学的学科.
背景情况:
- 绝经后的女性经历了氧化 (NO) 的生物可用性降低,影响了微循环和导管动脉,增加了心血管疾病 (CVD) 风险.
- 酸盐食补充剂显示出血管改善的潜力,但研究往往缺乏长期数据,并专注于上肢血管.
研究的目的:
- 评估12周酸盐丰富的甜菜提取物补充剂是否能改善绝经后妇女的下肢导管动脉和骨肌肉微血管功能.
- 评估补充剂对血清血管生成潜力的影响.
主要方法:
- 随机对照试验涉及绝经后妇女 (60-85岁),每天接受酸盐丰富 (8.8毫米) 或酸盐贫乏 (0.7毫米) 甜菜提取物,持续12周.
- 通过流媒扩张 (FMD) 评估的股骨动脉内皮功能;靠近红外光谱测量的骨前部微血管反应.
- 使用内皮管形成试验评估血清血管生成潜力.
主要成果:
- 血清酸盐水平在富含酸盐的组显著增加.
- 在12周后,在股骨动脉口炎中观察到显著的改善.
- 前部微血管反应在8周和12周增加.
- 从补充参与者的血清增强了体外管形成的1.8倍.
结论:
- 在绝经后的妇女中,为期12周的富含酸盐的甜菜提取物补充剂增强了下肢血管功能和血清血管生成潜力.
- 这种饮食策略可以减轻与更年期相关的血管功能障碍,并降低老年女性心血管疾病风险.
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