神经血管合功能障碍与认知和阿尔茨海默氏病连续体沿线的状纤维酸蛋白有关
Huijuan Chen1,2, Yihao Guo1, Zhanrong Zhang1
1Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University),, Haikou, P.R. China.
Journal of Alzheimer's disease : JAD
|September 12, 2025
概括
神经血管合功能障碍与阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 的认知衰退有关. 减少合与较差的认知和高的GFAP相关,表明作为早期AD生物标志物的潜力.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 生物标志物 生物标志物
背景情况:
- 神经血管合 (NVC) 功能障碍是阿尔茨海默病 (AD) 的早期病理特征,但其机制仍然不清楚.
- 了解AD连续性的NVC变化对于早期检测和干预至关重要.
研究的目的:
- 调查患有AD,轻度认知障碍 (MCI) 和认知正常 (CN) 个体的NVC变化.
- 检查NVC与认知表现和血生物标志物 (例如GFAP) 的关联.
主要方法:
- 使用功能性MRI (fMRI) 来评估神经元活动 (ALFF,ReHo) 和脑血流 (CBF).
- 使用ALFF-CBF和ReHo-CBF合的量化的NVC.
- 分析了23名CN,80名MCI和33名AD参与者的群体差异和与认知得分和血GFAP水平的相关性.
主要成果:
- 与CN和MCI组相比,AD患者在前和中带环环中显示出减少的ALFF-CBF合.
- 减少合与迷你精神状态考试成绩有正相关.
- 在认知障碍群体中,左前带环合减少与更高的血GFAP水平有关;阿兹海默症患者也减少了ReHo-CBF合.
结论:
- 神经血管合功能障碍与AD连续性的认知障碍有显著的相关性.
- ALFF-CBF合变化与认知衰退和高GFAP相关,突出了血管代谢和星质的作用.
- ALFF-CBF合显示为早期AD检测和监测的非侵入性生物标志物具有前途.
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