在癌症相关视网膜病变中,亨尔纤维层高反射性 (ASHH) 的角标志
Alessandro Feo1,2, Marko M Popovic1, Edmund Tsui1
1Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Ocular immunology and inflammation
|September 12, 2025
概括
癌症相关视网膜病变 (CAR) 在OCT上具有亨尔纤维层超反射性 (ASHH) 的角度标志,表明视力迅速丧失. ASHH可能表明早期的光受体毒性和偏膜瘤视网膜病变的不良预后.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 癌症相关视网膜病变 (CAR) 是一种针对光受体的自身免疫性疾病.
- 早期发现和了解CAR进展对于患者的治疗结果至关重要.
- 多式成像在诊断和监测视网膜疾病中起着关键作用.
研究的目的:
- 描述两个CAR患者的纵向多式成像发现.
- 在光谱域光学连贯性断层扫描 (SD-OCT) 上研究亨尔纤维层超反射性 (ASHH) 的角标志的意义.
- 为了将成像发现与临床表现和预后相关联.
主要方法:
- 追溯的案例系列.
- 对光谱域光学连贯性断层扫描 (SD-OCT) 结果的分析.
- 图像特征与视觉敏度和视野数据的相关性.
主要成果:
- 两名患有全身恶性瘤 (子宫内膜癌和前列腺癌) 的患者呈现双边ASHH病变.
- 在ASHH病变之前,有显著的圆形区域 (EZ) 损失和外视网膜缩.
- 两位患者都经历了迅速的视力丧失和不良的功能结果,尽管治疗.
结论:
- 在OCT上的ASHH病变可以作为偏膜性视网膜病变中光受体毒性的早期生物标志物.
- ASHH的存在表明疾病的进展很快.
- ASHH与癌症相关视网膜病变的预后不良因素有关.
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