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在自闭症谱系障碍中使用psilocybin:一个范围审查
Jaime Moreno-Chaparro1,2, Gabriela Castañeda-Millán1, Javier Eslava Schmalbach2,3
1School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
Clinical neuropharmacology
|September 12, 2025
概括
低剂量的psilocybin显示出对自闭症谱系障碍 (ASD) 症状的治疗信号,包括改善同情心和减少痛苦,没有显著的副作用. 随着迷幻研究的扩大,需要进一步的高证据研究.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 人们对神经精神疾病的迷幻药越来越感兴趣.
- 自闭症谱系障碍 (ASD) 是一种发育性神经精神疾病.
- 在ASD中 psilocybin 的作用的有限合成.
研究的目的:
- 综合现有关于在ASD患者中使用psilocybin的信息.
- 审查在ASD中的 псилоцибин处方,结果和药理变量.
- 评估psilocybin在ASD治疗中的治疗潜力.
主要方法:
- 覆盖范围审查方法.
- 搜索了Medline,EMBASE,SCOPUS,LILACS,科学网络直到2024年6月.
- 包括对自闭症患者群体中的 псилоцибин的研究,分析结果和剂量.
主要成果:
- 包括四项研究,表明psilocybin用于认知刚性,恐惧,社会困难.
- 在两项研究中指出了微剂量和特定间隔.
- 观察到同情心,情感性,社交性增加和症状减少;证据水平低.
结论:
- 在一些自闭症个体中,低剂量的西是一种治疗信号.
- 没有报告有毒或破坏性影响.
- 需要更高的证据水平研究,因为psilocybin限制放松.
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