瘤和正常组织的辐射敏感性:2025年更新
Ariane Lapierre1, Jeanne Monge-Cadet2, Muriel Brengues3
1Département de radiothérapie oncologie, centre hospitalier universitaire Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France; Université de Lyon, 69000 Lyon, France.
概括
个性化放射瘤学正在推进新的测试,以预测瘤反应和正常组织毒性. 这些测定旨在量身定制治疗,通过考虑个体辐射敏感性风险来改善患者护理.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 生物标志物 生物标志物
背景情况:
- 个性化瘤和放射治疗对于患者护理至关重要.
- 许多测试存在,以预测瘤反应和辐射毒性,但不是常规使用.
- 放射性瘤学的进步使得个性化策略能够考虑瘤复发和正常组织反应.
研究的目的:
- 审查用于预测瘤辐射敏感性和正常组织毒性的测试的现状.
- 突出有希望的生物标志物及其临床整合的证据水平.
- 讨论基于个人辐射敏感性的个性化放射治疗的潜力.
主要方法:
- 关于放射性敏感性预测试验的现有文献的审查.
- 评估瘤和正常组织辐射敏感性测试的证据水平.
- 讨论新兴的生物标志物,如放射学及其潜力.
主要成果:
- 没有瘤辐射敏感性测试在临床使用中;辐射敏感性指数和基因组调整放射治疗剂量的模型显示出希望 (II级证据).
- 放射学为新的生物标志物提供了潜力,目前正在进行前性研究.
- 正常组织辐射敏感性预测具有前列腺癌和头癌中单核酸多态性 (SNPs) 的I级证据,以及乳腺癌和前列腺癌的CD8 T-淋巴细胞亡试验.
结论:
- 个性化放射治疗可以根据预测瘤和正常组织辐射敏感性的测试进行量身定制.
- 一级和二级证据支持分别对正常组织和瘤辐射敏感性的特定测试.
- 这些预测测试可以在治疗开始前指导放射治疗决策.
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