Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Bone Structure

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Spinal cord imaging for multiple sclerosis: Advances, priorities, and opportunities.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026

Same author

A comparative study of deep learning for cortical lesion MRI segmentation with explainability analysis in multiple sclerosis.

NeuroImage. Clinical·2026

Same author

Automatic multiple sclerosis lesion segmentation in the spinal cord using 3 T and 7 T MP2RAGE images.

Multiple sclerosis and related disorders·2026

Same author

Serum Neurofilament Light Chain and GFAP Levels Are Associated with Structural Brain Connectivity in Parkinson's Disease.

International journal of molecular sciences·2026

Same author

Serum Glial Fibrillary Acidic Protein and Retinal Neuronal Loss as Additive Prognostic Markers of Disability in Multiple Sclerosis.

Neurology(R) neuroimmunology & neuroinflammation·2026

Same author

Structure-function multilayer network integration and cognition in multiple sclerosis.

Network neuroscience (Cambridge, Mass.)·2026

Same journal

Decoding functional changes in the brain following ischemic stroke: a multimodal feature approach integrating fNIRS with machine learning and deep learning.

NeuroImage. Clinical·2026

Same journal

Structural brain alterations in chronic primary pain: a multimodal MRI study.

NeuroImage. Clinical·2026

Same journal

Using functional MRI neurofeedback to modulate self-blame in major depressive disorder: A pilot study.

NeuroImage. Clinical·2026

Same journal

Language network reorganization in temporal lobe epilepsy: insights from task-based functional MRI.

NeuroImage. Clinical·2026

Same journal

Functional brain biomarkers of self-referential bias in remitted depressed outpatients: a randomized controlled trial.

NeuroImage. Clinical·2026

Same journal

Stress-related hypofrontality in depression and its relation to altered activation prior to the stress response.

NeuroImage. Clinical·2026

查看所有相关文章

Search research articles

相关实验视频

Updated: May 3, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

时间: Tractography-Informed 骨髓质蛋白估计时间:

Sara Bosticardo¹, Matteo Battocchio², Mario Ocampo-Pineda³

¹University of Verona, Diffusion Imaging and Connectivity Estimation (DICE) Lab, Department of Computer Science, Italy; University Hospital Basel and University of Basel, Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Switzerland; University Hospital and University Basel, Multiple Sclerosis Centre, Departments of Neurology, Clinical Research and Biomedicine, Switzerland; University Hospital Basel and University of Basel, Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Switzerland.

NeuroImage. Clinical

|September 12, 2025

概括

此摘要是机器生成的。

运通管信息化髓估计 (TIME) 量化了在多发性硬化症 (MS) 中的通道特异性髓损失. 这种新的方法揭示了髓损伤和神经障碍之间的显著关联,超过了传统的指标.

关键词:

焦点病变是指焦点病变的发生.多发性硬化症是多发性硬化症.骨髓蛋白是什么意思骨髓蛋白是什么意思曲谱学曲谱学曲谱学曲谱学曲谱学

更多相关视频

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

相关实验视频

Last Updated: May 3, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

科学领域:

神经成像是一种神经成像.
神经学神经学
生物标志物开发生物标志物开发

背景情况:

了解多发性硬化症 (MS) 病变和看起来正常的白质中的髓质完整性,是脱髓化和复髓化研究的关键.
目前的方法经常评估全球髓变化或将病变与健康对照进行比较,缺乏直接的轨道内比较.
有需要的方法可以量化管道特异性髓损失在单个白质通道内.

研究的目的:

引入和验证 Tractography-Informed Myelin Estimate (TIME),这是一个用于量化MS中通道特异性髓损失的新型地图.
评估TIME量化的髓损失与神经障碍在基线和纵向的关联.
为了比较TIME的灵敏度与传统的髓度量.

主要方法:

开发了 TIME 通过将 Traktography 与髓敏感成像 (髓体积分数) 结合起来,在同一白质通道内比较病变和非病变部分.
沿流线模拟了与预期的髓体积分数的局部偏差,以捕获通道特定的损伤.
在159名多发性硬化患者中评估了TIME,在基线和两年随访期间评估了与神经障碍的关联.

主要成果:

在基线时通过TIME测量的较高的髓损失显著与更严重的神经障碍相关 (β=0.14,p=0.015).
较大的基线残疾预测了较快的时间量化的髓损失,这与残疾恶化的风险增加有关.
损伤平均的髓体积分数没有显示出与基线残疾或其进展的显著关联.

结论:

时间提供了一种敏感的,管道特定的评估,对MS中髓损伤的评估.
时间表现出比评估髓损失的传统指标更高的灵敏度.
时间显示,它有可能成为MS的有价值的成像生物标志物,与残疾和疾病进展相关联.