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Updated: Jan 18, 2026

A High-throughput Assay for the Prediction of Chemical Toxicity by Automated Phenotypic Profiling of Caenorhabditis elegans

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Published on: March 14, 2019

和癌症:关于犬类瘤和环境生物指标 (Sus scrofa) 的研究

Filippo Dell'Anno¹, Roberta Giugliano¹, Livia De Paolis¹

¹National Reference Center of Veterinary and Comparative Oncology (CEROVEC), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Genoa, Italy.

Ecotoxicology and environmental safety

|September 12, 2025

概括

环境 (Cd) 污染与狗的瘤发生增加有关,特别是乳腺,生殖,皮肤和软组织瘤. 这突出了物作为比较瘤学模型,以了解环境致癌物和公共卫生风险.

科学领域:

比较瘤学的比较.
环境毒理学环境毒理学
兽医医学兽医医学兽医医学

背景情况:

物,特别是狗和猫,由于与人类癌症的相似之处,可以作为有价值的比较瘤学模型.
像 (Cd) 这样的重金属是公认的环境致癌物,与各种人类恶性瘤有关.
长期暴露于持续性,生物积累性有毒物质,如,在共享环境中构成显著的长期健康风险.

研究的目的:

调查生活在不同程度 (Cd) 污染地区的物中特定瘤的发生情况.
评估环境Cd污染对狗瘤发展的潜在贡献.

主要方法:

对1764只狗在不同Cd污染水平的地区的瘤发生率的分析.
利用单变量和多变量混合效应Poisson通用线性模型 (GLM) 来分析固定和随机效应.
检查了影响皮肤,软组织,乳腺,阴茎和丸的瘤.

主要成果:

具有非常高Cd污染的地区显示乳腺瘤的比例更高 (PMR = 64.68).
在高度污染的地区观察到阴茎和丸瘤 (PMR = 19.73),软组织瘤 (PMR = 100.55) 和皮肤瘤 (PMR = 116.23) 的比例增加.
统计模型表明,环境Cd污染与狗中这些特定瘤类型的发生率增加之间存在显著的关联.

结论:

环境中的污染对狗的乳腺,阴茎和丸,皮肤和软组织瘤的发展起着作用.
这些发现强调了比较瘤学在理解癌症病因学的重要性.
这项研究强调需要改进针对环境致癌物质的公共卫生战略.

关键词:

比较性瘤学研究狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗流行病学流行病学暴露于重金属中的重金属.这是PMR的PMR.

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