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基于菌的生物活性氧气发生器用于持续的瘤缺氧缓解和组合模式的瘤治疗

Can Zhang¹, Shiqi Liu¹, Yuqing Cao¹

¹Nano-biotechnology Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China; Applying Chemistry Key Lab of Hebei Province, Yanshan University, Qinhuangdao 066004, PR China.

Journal of colloid and interface science

|September 12, 2025

概括

一种新的Chlorella pyrenoidosa和二硫化物复合系统产生氧气以重塑瘤微环境,增强癌症治疗和免疫反应.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
癌症治疗癌症治疗

背景情况:

缺氧瘤微环境 (TME) 驱动瘤的进展和抵抗.
目前的氧气敏感化策略在交付,有效性和副作用方面面临挑战.

研究的目的:

开发一种复合系统 (C@W) 以实现协同抗瘤功效.
为了利用Chlorella pyrenoidosa (CHL) 光合作用和二硫化 (WS2) 光催化.
为了重塑TME,增强治疗,并激活免疫系统.

主要方法:

使用CHL和WS2开发了一个生物-无机混合平台 (C@W).
利用660nm近红外 (NIR) 光用于光合作用和光催化.
研究了TME调节,癌细胞死亡和免疫细胞反应.

主要成果:

CHL光合作用持续提供氧气,抑制缺氧诱导因子-α (HIF-α).
WS2光催化产生了细胞毒性单片氧 (1O2).
该系统诱导了免疫细胞死亡 (ICD),促进了树突细胞成熟,M2到M1巨细胞两极分化,并增加了CD8+ T细胞.

结论:

C@W平台提供双引擎氧气自供系统 (光合作用-光催化剂).
它克服了传统增氧疗法的局限性.
这种方法协同缓解免疫抑制,并将TME调节与免疫激活相结合,用于固体瘤治疗.

关键词:

缓解缺氧缓解缺氧克洛瑞拉 (Chlorella pyrenoidosa) 是一种天然的植物.免疫原性细胞死亡免疫治疗是一种免疫疗法.光催化疗法是一种光催化疗法.

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