林氏素耐药基因 lnu(C) 携带的Campylobacter jejuniuni基因的表征
Wenjun Li1, Shuaiwei Ge1, Yong Liu1
1College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, PR China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, PR China; Key Laboratory of Quality and Safety Control of Poultry Products, Ministry of Agriculture and Rural Affairs, PR China.
Veterinary microbiology
|September 12, 2025
概括
林科萨米德耐药性基因lnu(C) 在Campylobacter jejuni中分布在全球,主要来自食用动物和人类. 这项研究强调了其在横向基因转移和动物传播方面的潜力,特别是在中国.
科学领域:
- 兽医微生物学 兽医微生物学
- 食品安全 食品安全
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 林氏素对兽医至关重要,但Campylobacter jejuni的林氏素耐药性尚未得到充分了解.
- 坎比洛巴克特 (Campylobacter jejuni) 是一种严重的食源性病原体,影响动物和人类.
研究的目的:
- 综合分析Campylobacter jejuni.中的lnu(C) 耐药性基因的全球分布和遗传特征.
- 为了调查 lnu ((C) 阳性 C. jejuni 菌株的传播潜力和遗传相关性.
主要方法:
- 从全球来源 (GenBank和实验室) 分析了141个InuC阳性的C. jejuni菌株.
- 多部位序列类型 (MLST) 和全基因组MLST (Wg-MLST) 用于基因分析.
- 鉴定与lnu (C) 基因相关的遗传环境.
主要成果:
- lnu(C) 基因在C. jejuni中分布在全球,主要存在于食用动物,食品和人类分离物中,在中国 (46.1%) 患病率很高.
- MLST确定了44种序列类型,其中ST573是最常见的基因型,表明克隆扩张和水平传播.
- 类似MTnSag1的转位子[insLNU-lnu(C) ]是lnu(C最常见的遗传背景,在不同的地理区域和宿主中发现.
结论:
- 这项研究提供了一个详细的概述 lnu(C) 基因分布和传输动态在C. jejuni.
- 这些发现强调了携带C. jejuni菌株的显著动物感染潜力,因为它们存在于食用动物,食品和人类中.
- 了解这些模式对于管理抗菌素耐药性和食品安全至关重要.
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