牛奶脂肪球膜脂补充剂对老年人主观记忆障碍认知功能的影响 - 一个随机,双盲,安慰剂控制的随机试验
Ian T Zajac1, Naomi Kakoschke2, Stefanie Evas3
1Health & Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Adelaide, Australia; Flinders University, College of Education Psychology and Social Work, Adelaide, South Australia.
The American journal of clinical nutrition
|September 12, 2025
概括
乳脂球体膜 (MFGM) 脂在老年人中没有显著改善认知功能. 然而,高剂量MFGM补充剂在测试期间提高了警觉性,并对炎症和胆固醇水平产生了积极影响.
科学领域:
- 营养神经科学 营养神经科学
- 老年学是一门学科.
- 临床试验 临床试验
背景情况:
- 关于牛奶脂肪球体膜 (MFGM) 脂对健康老年人认知功能的证据有限.
- 众所周知,MFGM脂对认知功能有益,特别是在婴儿身上.
研究的目的:
- 调查MFGM脂补充剂对55-75岁成年人认知功能和其他健康结果的影响.
- 与安慰剂相比,评估低剂量和高剂量MFGM补充剂的影响.
主要方法:
- 一个多中心,随机,双盲,安慰剂控制的试验,涉及263名参与者.
- 参与者每天接受低剂量MFGM (1.7g脂),高剂量MFGM (4.0g脂) 或粉安慰剂16周.
- 认知,行为,生化和物理测量在基线,第8周和终点被评估.
主要成果:
- 在初级 (RBANS) 或二级 (COMPASS) 认知结果中没有观察到显著的改善.
- 在高剂量MFGM组中,认知测试期间的主观警觉性得到改善.
- 补充MFGM降低了TNF-α,胆固醇和LDL,并增加了GABA,血清素和活性B12. 在高剂量MFGM时,同类半氨酸倾向于降低.
结论:
- 虽然认知功能没有显著改善,但高剂量的MFGM在测试期间提高了警觉性.
- 补充MFGM证明了与认知衰退相关的心血管健康标志物 (炎症,胆固醇,LDL) 的潜在益处.
- 对B12和同氨酸的积极影响表明潜在的大脑健康益处,为认知结果提供了长期研究的理由.
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