pH-敏感的烯酸接种 Abelmoschus esculentus 复合物,用于持续释放 pantoprazole
Maryam Basharat1, Sobia Noreen1, Shazia Akram Ghumman2
1Institute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan.
概括
这项研究开发了一种来自Abelmoschus esculentus粘液的pH敏感水凝,用于在炎症性肠道疾病中向药物输送. 移植复合物显示在胃肠道中安全,可控释放PAS,改善治疗结果.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 胃肠病学 胃肠病学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,需要有效和有针对性的治疗策略.
- 目前的治疗方法经常面临系统性副作用和疾病部位低于最佳的药物度的挑战.
- 阿贝尔莫斯克 (Abelmoschus esculentus) 粘液 (AEM) 为开发新型药物输送系统提供了一种生物相容的天然聚合物.
研究的目的:
- 来自AEM的pH敏感的烯酸植入水凝复合物的合成和特征,用于增强药物输送.
- 评估开发用于治疗IBD的水凝的药物释放动力学和体内性能.
- 评估基于AEM的移植复合物的生物相容性和安全性,用于治疗应用.
主要方法:
- 通过将烯酸移植到AEM上,合成pH敏感的水凝.
- 使用FT-IR光谱,SEM和XRD进行表征,以确认接种和结构.
- 在不同的pH条件下 (酸性和性) 模拟胃肠道的体外药物释放研究.
- 使用Korsmeyer-Peppas模型分析释放动力学.
- 生物相容性测试包括细胞毒性,血液相容性和急性口服毒性.
- 在体内药理动力学研究以确定模型药物的半衰期 (PAS).
主要成果:
- 通过光谱和显微分析证实了多孔,pH敏感的移植复合物的成功合成.
- 控制释放PAS,在酸性条件下释放速度较慢,在性条件下释放速度较快.
- 药物释放遵循Korsmeyer-Peppas模型,表明非Fickian扩散,特别是在性介质 (R2 > 0.987) 中.
- 移植复合物通过各种毒性评估证明了出色的生物相容性和安全性.
- 在体内研究表明,PAS半衰期从1.119小时显著增加到4.395小时.
结论:
- 开发的pH敏感的基于AEM的水凝是一种有前途的生物相容材料,用于在结肠中向药物输送.
- 这种系统可以控制和增强治疗剂的释放,提高炎症性肠道疾病的疗效.
- 这项研究强调了开发用于胃肠道疾病的先进药物输送系统的重大进展.
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