慢性疼痛和主观记忆问题是功能衰退的动态风险因素:一个ACTIVE纵向研究
Tyler R Bell1, Cynthia Felix2, Nathalie Gider3
1Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Experimental gerontology
|September 12, 2025
概括
老年人的主观记忆问题 (SMP) 和慢性疼痛与更糟糕的认知,身体和心理健康有关. 慢性疼痛加剧了SMPs对推理和身体功能的负面影响.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 慢性疼痛和主观记忆问题 (SMPs) 在老年人中很普遍.
- 这两种情况都与功能衰退,残疾和痴呆症风险有关.
研究的目的:
- 检查SMP与老年人的认知,身体和心理社会功能之间的关联.
- 研究慢性疼痛作为这些关联的调节者.
主要方法:
- 利用了2365名参与者在"独立和活力老年人高级认知培训 (ACTIVE) "研究中的数据.
- 采用多层模型来评估基线和时间变化的SMP和慢性疼痛.
- 评估认知 (记忆,推理,处理速度),身体 (移动性,握力,自我评估的健康) 和心理 (抑郁症状,社会功能) 的结果.
主要成果:
- 较大的SMP与较差的基线认知表现有关.
- SMP和慢性疼痛独立地与更糟糕的身体和社会功能以及更多的抑郁症状有关.
- 慢性疼痛独特地预测了流动性和握力减少.
- SMP与慢性疼痛相互作用,预测推理和身体功能的急剧下降.
- SMP的增加与认知,身体和心理社会领域的下降相关.
结论:
- SMPs是老年人功能衰退的重要预测因素,特别是那些患有慢性疼痛的人.
- 共同考虑SMP和慢性疼痛对于识别面临加速功能衰退风险的老年人至关重要.
- 针对记忆问题和疼痛管理的干预措施可能对这个人群有益.
相关概念视频
Interference and Decay
423
Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
423
Long-term Depression
3.1K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
3.1K
Alzheimer's Disease: Overview
1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Dementia
526
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
526
Traumatic Memory
552
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
552
Analgesia and Pain Management
1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K


