创新的双层口腔膜:一种适合儿童的剂量形式,用于通过粘膜输送阿齐思罗米辛
Giulia Bondi1, Ilenia D'Abbrunzo2, Dritan Hasa2
1University of Bologna, Department of Pharmacy and Biotechnology, Via San Donato 19/2, Bologna, Italy.
International journal of pharmaceutics
|September 12, 2025
概括
这项研究开发了新型的粘膜膜,用于在儿童中输送阿兹胺素 (AZT). 嘴膜改善了药物的吸收,并掩盖了苦味,提供了更有效的抗生素治疗选择.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 阿齐思罗米 (AZT) 是一种被广泛处方的儿科抗生素,其局限性包括溶解性差,生物可用性和苦味.
- 这些因素会对治疗疗效和儿科患者口服药物的遵守产生负面影响.
研究的目的:
- 开发和描述粘膜粘合性口腔膜,以改善儿童的阿齐思罗米辛输送.
- 为了提高药物的溶解性,控制释放,确保单向吸收,并掩盖阿齐思罗米的苦味.
主要方法:
- 使用酸盐 (CS),酸盐 (ALG) 和酸 (HYA) 等聚合物配合溶解剂 (Soluplus®,聚烯酸) 的粘粘膜的配方.
- 薄膜的物理特性,药物含量,固态分析 (PXRD,FT-IR),粘膜粘合,机械强度,以及体外药物释放/透的特性.
- 对抗微生物活性和口味掩饰潜力的评估.
主要成果:
- 开发了各种聚合物基 (CS,ALG,HYA) 的均,薄的粘膜.
- 素膜显示出由于一种更易溶解的药物形式而快速释放亚齐胺,而HYA和ALG膜显示出持续释放.
- 支持层有效地限制了药物释放,并掩盖了苦味. 在HYA膜中,药物透率最佳,抗菌活性保持.
结论:
- 粘粘性口腔膜提供了一个有前途的系统,用于阿齐思罗米辛的输送,通过口腔粘膜改善全身吸收.
- 基于HYA的薄膜配方特别适用于阿齐思罗米辛口服,提高了疗效和患者的遵守性.
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