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用细菌纤维素基菌粒准和逆转瘤酸性微环境,以增强免疫透

Shuangjun Li¹, Ruyue Shi¹, Yankun Liu¹

¹Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, 150040, PR China; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, 150040, PR China; Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin, 150040, PR China; Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-based Active Substances, Harbin, 150040, PR China.

International journal of biological macromolecules

|September 12, 2025

概括

这项研究引入了一种使用细菌纤维素纳米粒子来逆转瘤酸度的新疗法. 这种方法通过重聚巨细胞和恢复T细胞抗瘤功能来增强免疫疗法,有效地打击瘤进展.

科学领域:

生物医学工程生物医学工程
癌症研究癌症研究
免疫学免疫学免疫学

背景情况:

瘤酸性抑制免疫细胞的功能,阻碍抗癌反应.
逆转瘤酸度是一种有前途的策略,可以提高免疫治疗的疗效.

研究的目的:

开发和评估一种基于细菌纤维素的纳米粒子系统,用于逆转瘤酸度.
为了研究这种疗法在复极化巨细胞和恢复T细胞抗瘤活性方面的潜力.

主要方法:

用叶酸 (FA) 和 (BY) 修饰的细菌纤维素 (BC) 复合纳米颗粒的制造.
用温克里斯 (VCR) 和GNE-140加载纳米粒子以中和乳酸并抑制乳酸脱酶.
评估纳米粒子在逆转瘤酸度,诱导瘤细胞死亡和调节免疫微环境方面的有效性.

主要成果:

FA-BC-BY@VCR@GNE-140纳米颗粒有效地逆转了瘤的酸性.
治疗诱导了瘤细胞死亡,并在瘤微环境内减轻了免疫抑制.
刺激了宿主适应性免疫力,表明恢复了抗瘤功能.

结论:

针对细菌纤维素的菌提供了一种创新的策略,用于逆转瘤酸度.
这种方法将化疗和免疫疗法协同使用,以对抗瘤进展.
开发的纳米粒子显示了提高癌症治疗疗效的潜力.

关键词:

细菌纤维素的细菌纤维素.免疫系统的透.微粒微粒 (Micelles) 是一种微粒.瘤中的酸性微环境

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