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Updated: May 1, 2026

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
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5xFAD突变导致Ahl纠正的5xFAD小鼠的听力损伤

Hongguo Su1, Fan Wu2, Khujista Haque2

  • 1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.

Experimental neurology
|September 12, 2025
PubMed
概括

这就是阿尔茨海默病的原因.

关键词:
声学惊反应 (ASR) 的减少.与年龄相关的听力损伤 (ARHI)在Ahl校正的C57BL/6-背景5xFAD小鼠 (FAD2) 中.粉样蛋白沉积的沉积听觉神经的过度刺激性螺旋质神经元 (SGN) 髓退化 髓退化

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相关概念视频

Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
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